Serotransferrin (TF) Active Protein | TF active protein

Recombinant Human Serotransferrin (TF)(Active)

Cat. Num. AAA279228

• Gene Names: TF; TFQTL1; PRO1557; PRO2086
• Purity: Greater than 95% as determined by SDS-PAGE.
• Synonyms: Serotransferrin (TF); N/A; Recombinant Human Serotransferrin (TF)(Active); Transferrin; Beta-1 metal-binding globulin; Siderophilin; TF; PRO1400; TF active protein

• Host: Mammalian cell
• Purity/Purification: Greater than 95% as determined by SDS-PAGE.
• Form/Format: Lyophilized powder; Lyophilized from a 0.2 um filtered PBS, 6% Trehalose, pH 7.4
• Sequence Positions: 20-698aa; Full Length of Mature Protein
• Sequence: VPDKTVRWCAVSEHEATKCQSFRDHMKSVIPSDGPSVACVKKASYLDCIRAIAANEADAVTLDAGLVYDAYLAPNNLKPVVAEFYGSKEDPQTFYYAVAVVKKDSGFQMNQLRGKKSCHTGLGRSAGWNIPIGLLYCDLPEPRKPLEKAVANFFSGSCAPCADGTDFPQLCQLCPGCGCSTLNQYFGYSGAFKCLKDGAGDVAFVKHSTIFENLANKADRDQYELLCLDNTRKPVDEYKDCHLAQVPSHTVVARSMGGKEDLIWELLNQAQEHFGKDKSKEFQLFSSPHGKDLLFKDSAHGFLKVPPRMDAKMYLGYEYVTAIRNLREGTCPEAPTDECKPVKWCALSHHERLKCDEWSVNSVGKIECVSAETTEDCIAKIMNGEADAMSLDGGFVYIAGKCGLVPVLAENYNKSDNCEDTPEAGYFAIAVVKKSASDLTWDNLKGKKSCHTAVGRTAGWNIPMGLLYNKINHCRFDEFFSEGCAPGSKKDSSLCKLCMGSGLNLCEPNNKEGYYGYTGAFRCLVEKGDVAFVKHQTVPQNTGGKNPDPWAKNLNEKDYELLCLDGTRKPVEEYANCHLARAPNHAVVTRKDKEACVHKILRQQQHLFGSNVTDCSGNFCLFRSETKDLLFRDDTVCLAKLHDRNTYEKYLGEEYVKAVGNLRKCSTSSLLEACTFRRP$

• Species: Homo sapiens (Human)
• Tag: C-terminal hFc-tagged
• Endotoxin: Less than 1.0 EU/ug as determined by LAL method.
• Research Area: Cancer
• Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TFRC at 2 ug/mL can bind Human TF. The EC50 is 58.72-77.84 ng/mL.
• Preparation and Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.; Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.; We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Bioactivity

(Measured by its binding ability in a functional ELISA. Immobilized TFRCat 2?g/mL can bind Human TF, the EC50 is 58.72-77.84 ng/mL.)

SDS-PAGE

((Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.)

Related Product Information for TF active protein

Transferrins are iron binding transport proteins which can bind two Fe3+ ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation.Serves as an iron source for Neisseria species, which capture the protein and extract its iron for their own use.Serves as an iron source for parasite T.brucei (strain 427), which capture TF via its own transferrin receptor ESAG6:ESAG7 and extract its iron for its own use.

Product Categories/Family for TF active protein

Active Protein & In Stock Protein

References

"Human transferrin: cDNA characterization and chromosomal localization."Yang F., Lum J.B., McGill J.R., Moore C.M., Naylor S.L., van Bragt P.H., Baldwin W.D., Bowman B.H.Proc. Natl. Acad. Sci. U.S.A. 81:2752-2756 (1984)"Complete structure of the human transferrin gene. Comparison with analogous chicken gene and human pseudogene."Schaeffer E., Lucero M.A., Jeltsch J.-M., Py M.-C., Levin M.J., Chambon P., Cohen G.N., Zakin M.M.Gene 56:109-116 (1987)"A cloned gene for human transferrin."Hershberger C.L., Larson J.L., Arnold B., Rosteck P.R. Jr., Williams P., Dehoff B., Dunn P., O'Neal K.L., Riemen M.W., Tice P.A.Ann. N. Y. Acad. Sci. 646:140-154 (1991)

NCBI and Uniprot Product Information

• NCBI GI #: 339453
• NCBI GeneID: 7018
• UniProt Accession #: P02787; O43890; Q1HBA5; Q9NQB8; Q9UHV0
• Molecular Weight: 77,064 Da
• NCBI Official Full Name: transferrin
• NCBI Official Synonym Full Names: transferrin
• NCBI Official Symbol: TF
• NCBI Official Synonym Symbols: TFQTL1; PRO1557; PRO2086
• NCBI Protein Information: serotransferrin; siderophilin; beta-1 metal-binding globulin
• UniProt Protein Name: Serotransferrin
• UniProt Gene Name: TF
• UniProt Synonym Gene Names: Transferrin
• UniProt Entry Name: TRFE_HUMAN