Tau-441 (2N4R) P301S Mutant Protein Filaments Recombinant Protein | Tau-441 recombinant protein

Human Recombinant Tau-441 (2N4R) P301S Mutant Protein Filaments

Cat. Num. AAA254093

• Gene Names: MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• Applications: SDS-Page, Western Blot
• Purity: >95%; Ion-exchange Purified
• Synonyms: Tau-441 (2N4R) P301S Mutant Protein Filaments; N/A; Human Recombinant Tau-441 (2N4R) P301S Mutant Protein Filaments; Tau-441 (2N4R) P301S Mutant Filaments; Tau-441 (2N4R) P301S Mutant; Tau filament; Tau protein; microtubule-associated protein Tau; MAPT; MAP; microtubule-associated protein; Tau Protein Aggregate; Paired Helical Filament-Tau; Phf-Tau; Neurofibrillary Tangle Protein; G Protein Beta1/Gamma2 Subunit-Interacting Factor 1; Isoform 2; tubulin-associated unit; Tau-441 recombinant protein

• Host: E coli
• Purity/Purification: >95%; Ion-exchange Purified
• Form/Format: PBS pH 7.4, 5 mM DTT, 2 mM MgCl2
• Concentration: Lot/batch specific. See included datasheet. (varies by lot)
• Sequence Length: Full length

• Applicable Applications for Tau-441 recombinant protein: Invitro Assay, SDS-PAGE, WB (Western Blot)
• Species: Human
• Conjugation: No tag
• Research Area: Alzheimer's Disease, Axon Markers, Cell Markers, Cell Signaling, Cytoskeleton, Microtubules, MT Associated Proteins, Neurodegeneration, Neuron Markers, Neuroscience, Tangles & Tau
• Cellular Localization: Cytoplasm, Axolemma, Axolemma Plasma Membrane, Axon, Cell Body, Cell membrane, Cytoplasmic Ribonucleoprotein Granule, Cytoplasmic Side, Cytoskeleton, Cytosol, Dendrite, Growth cone, Microtubule, Microtubule Associated Complex, Neurofibrillary Tangle, Neuronal Cell Body, Nuclear Periphery, Nuclear Speck, Nucleus, Peripheral membrane protein, Plasma Membrane, Tubulin Complex
• Certificate of Analysis: Certified >95% pure using SDS-PAGE analysis.
• Other Relevant Information: For best results, sonicate immediately prior to use. Refer to the Neurodegenerative Protein Handling Instructions on our website, or on the product datasheet for further information.
• Preparation and Storage: Store at -80 degree C

Application Data

(TEMofHumanRecombinantTauProteinFilaments(AAA254093))

Application Data

(TEMofHumanRecombinantTauProteinFilaments(AAA254093))

Related Product Information for Tau-441 recombinant protein

Alzheimer's Disease (AD) is the most common neurodegenerative disease, affecting 10% of seniors over the age of 65 (1). It was named after Alois Alzheimer, a German scientist who discovered tangled bundles of fibrils where neurons had once been in the brain of a deceased patient in 1907 (2). Tau (tubulin-associated unit) is normally located in the axons of neurons where it stabilizes microtubules. Tauopathies such as AD are characterized by neurofibrillary tangles containing hyperphosphorylated tau fibrils (3). There are six isoforms of tau in the adult human brain: three with four repeat units (4R) and three with three repeat units (3R)(4). K18 is a truncated form of human tau containing only the 4 microtubule binding repeats (5). P301L (PL) is a mutation where proline is replaced by leucine at codon 301 of tau, and has been linked to frontotemporal dementia (6).

Product Categories/Family for Tau-441 recombinant protein

Proteins

References

1. www.alz.org/alzheimers-dementia/facts-figures2. Alzheimer, A. Über eine eigenartige Erkrankung der Hirnrinde. Allg. Z. Psychiatr. Psych.-Gerichtl. Med. 64, 146-148 (1907)3. Matsumoto, G. et al. (2018). Int J Mol Sci. 19, 1497.4. Goedert, M. and Spillantini, M. G. (2017). Mol Brain. 10:18.5. Guo, J. and Lee, M.Y. (2013). FEBS Lett. 587(6): 717-723.6. Alberici, A. et al. (2004). J Neurol Neurosurg Psychiatry. 75:1607-1610.

NCBI and Uniprot Product Information

• NCBI GI #: 6754638
• NCBI GeneID: 4137
• NCBI Accession #: NP_005901.2
• NCBI GenBank Nucleotide #: NM_005910.5
• UniProt Accession #: P10636; P18518; Q14799; Q15549; Q15550; Q15551; Q1RMF6; Q53YB1; Q5CZI7; Q5XWF0; Q6QT54; Q9UDJ3
• Molecular Weight: 80,941 Da
• NCBI Official Full Name: microtubule-associated protein tau isoform 2
• NCBI Official Synonym Full Names: microtubule-associated protein tau
• NCBI Official Symbol: MAPT
• NCBI Official Synonym Symbols: TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103
• NCBI Protein Information: microtubule-associated protein tau; PHF-tau; paired helical filament-tau; neurofibrillary tangle protein; microtubule-associated protein tau, isoform 4; protein phosphatase 1, regulatory subunit 103; G protein beta1/gamma2 subunit-interacting factor 1
• UniProt Protein Name: Microtubule-associated protein tau
• UniProt Gene Name: MAPT
• UniProt Synonym Gene Names: MAPTL; MTBT1; TAU; PHF-tau
• UniProt Entry Name: TAU_HUMAN