Mouse anti-Human Angiotensin I Converting Enzyme (ACE)/CD143 Monoclonal Antibody | anti-ACE antibody

Angiotensin I Converting Enzyme (ACE)/CD143

Cat. Num. AAA214920

• Gene Names: ACE; DCP; ACE1; DCP1; CD143
• Reactivity: Human
• Applications: Immunohistochemistry, ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Angiotensin I Converting Enzyme (ACE)/CD143, Antibody; Angiotensin I Converting Enzyme (ACE)/CD143; ACE; ACE1; angiotensin 1 converting enzyme 1; carboxycathepsin; CD143; CD143 antigen; DCP; DCP1; dipeptidyl carboxypeptidase 1; Kininase II; MVCD3; peptidase P; testicular ECA; anti-ACE antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: 9B9
• Specificity: This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes - the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 32

• Applicable Applications for anti-ACE antibody: IHC (Immunohistochemistry), ELISA
• Positive Control: Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate.
• Immunogen: Full-length recombinant human ACE/CD143 protein
• Cellular Localization: Cell Surface
• Hu-chromosome Location: 17q23.3
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human small intestine stained with ACE/CD143 Mouse Monoclonal Antibody (9B9).)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human small intestine stained with ACE/CD143 Mouse Monoclonal Antibody (9B9).)

SDS-PAGE

(SDS-PAGE Analysis Purified ACE/CD143 Mouse Monoclonal Antibody (9B9). Confirmation of Integrity and Purity of Antibody.)

References

Morell NW et al. Cardiovasc Res. 1997 May;34(2):393-403.

NCBI and Uniprot Product Information

• NCBI GI #: 76057114
• NCBI GeneID: 1636
• UniProt Accession #: P12821
• Molecular Weight: 195kDa
• NCBI Official Full Name: angiotensin I converting enzyme, partial
• NCBI Official Synonym Full Names: angiotensin I converting enzyme
• NCBI Official Symbol: ACE
• NCBI Official Synonym Symbols: DCP; ACE1; DCP1; CD143
• NCBI Protein Information: angiotensin-converting enzyme
• UniProt Protein Name: Angiotensin-converting enzyme
• UniProt Gene Name: ACE
• UniProt Synonym Gene Names: DCP; DCP1; ACE
• UniProt Entry Name: ACE_HUMAN