IHC (Immunohiostchemistry)
(Annexin VII Antibody Immunohistochemistry on an FFPE Prostate Adenocarcinoma Tissue)
Rabbit anti-Human Annexin VII Monoclonal Antibody
Annexin VII (EP367)
Reactivity
Human
Synonyms
Annexin VII, Antibody; Annexin VII (EP367); annexin viii; anti-annexin viii; annexin 7; anti-annexin 7; anti annexin; anx7; anti-anx7 anx-7; anxvii; anti-anxvii; anti-Annexin VII antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
EP367
Form/Format
Paraffin, Frozen
Anti-Annexin VII is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Anti-Annexin VII is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Recombinant human Annexin VII protein.
Control
Breast, Colon, Kidney, Tonsil, Prostate, Testis, Transitional Cell Carcinoma
Localization
Nuclear, Cytoplasmic, Membranous
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(Annexin VII Antibody Immunohistochemistry on an FFPE Prostate Adenocarcinoma Tissue)
IHC (Immunohiostchemistry)
(Annexin VII Antibody Immunohistochemistry on an FFPE Prostate Adenocarcinoma Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-Annexin VII antibody
Annexin VII (or Annexin A7) is a Ca2+ -dependent and phospholipid-binding protein. It is encoded by the ANX7 gene, which is located in human chromosome 10q21. It is a member of the annexin protein family, which regulates various endomembrane processes including vesicle fusion, segregation, and compartmentalization and is implicated in plasma membrane repair mechanisms.
Studies suggest that ANX7 is a tumor suppressor gene and it was found that Annexin VII is associated with several types of cancers, such as Prostate, Breast, Liver, and Gastric cancer. IHC analysis showed that a low or the loss of expression of Annexin VII antibody correlates with Prostate cancer progression. On the contrary, high levels of Annexin VII expression were found in Metastatic Breast Tumors and that HER2-Negative patients suffer increased risk of death when ANX7 expression levels are elevated. Another study found that ANX7 predominantly shows low expression in other cancer types, such as Colon Adenocarcinoma or Bladder Transitional Cell Carcinoma. A study identified the prognostic impact of ANXA7 in Prostate Cancer using tissue microarrays, identified ANXA7 as a new prognostic factor and indicated a bimodal correlation to tumor progression. Another study concluded that Annexin A7 expression was able to inhibit HCC lymph node metastasis, whereas knockdown of Annexin A7 expression significantly induced HCC metastasis to local lymph nodes.
Studies suggest that ANX7 is a tumor suppressor gene and it was found that Annexin VII is associated with several types of cancers, such as Prostate, Breast, Liver, and Gastric cancer. IHC analysis showed that a low or the loss of expression of Annexin VII antibody correlates with Prostate cancer progression. On the contrary, high levels of Annexin VII expression were found in Metastatic Breast Tumors and that HER2-Negative patients suffer increased risk of death when ANX7 expression levels are elevated. Another study found that ANX7 predominantly shows low expression in other cancer types, such as Colon Adenocarcinoma or Bladder Transitional Cell Carcinoma. A study identified the prognostic impact of ANXA7 in Prostate Cancer using tissue microarrays, identified ANXA7 as a new prognostic factor and indicated a bimodal correlation to tumor progression. Another study concluded that Annexin A7 expression was able to inhibit HCC lymph node metastasis, whereas knockdown of Annexin A7 expression significantly induced HCC metastasis to local lymph nodes.
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Product Notes
The Annexin VII (Catalog #AAA59353) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Annexin VII (EP367) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Annexin VII, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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