Rabbit anti-Human Antithrombin III Monoclonal Antibody | anti-SerpinC1 antibody
Recombinant Anti-Antithrombin III Antibody, Rabbit Monoclonal
Gene Names
SERPINC1; AT3; AT3D; ATIII; THPH7
Reactivity
Human
Applications
ELISA
Purity
Protein A
Synonyms
Antithrombin III, Antibody; Recombinant Anti-Antithrombin III Antibody, Rabbit Monoclonal; SerpinC1/AntithrombinIII/ATIII Antibody, Rabbit MAb; serpin peptidase inhibitor, clade C (antithrombin), member 1; Anti-AT3 Antibody; Anti-AT3D Antibody; Anti-ATIII Antibody; Anti-MGC22579 Antibody; Anti-Serpin C1 Antibody; Anti-SerpinC1 Antibody; Anti-THPH7 Antibody; anti-SerpinC1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
023
Specificity
Human Serpin C1.
No cross-reactivity in ELISA with
Human SerpinA1, Human SerpinA3, Human SerpinA5, Mouse SerpinF2, Human SerpinF1, Human SerpinD1, Mouse SerpinD1
No cross-reactivity in ELISA with
Human SerpinA1, Human SerpinA3, Human SerpinA5, Mouse SerpinF2, Human SerpinF1, Human SerpinD1, Mouse SerpinD1
Purity/Purification
Protein A
Form/Format
0.2um filtered solution in PBS
Applicable Applications for anti-SerpinC1 antibody
ELISA
Antibody Type
Recombinant Antibody
Immunogen
Recombinant Human Serpin C1 protein
Conjugation
Unconjugated
Preparation
This antibody was obtained from a rabbit immunized with purified, recombinant Human Antithrombin III/ATIII/SerpinC1 (rh Antithrombin III/ATIII/SerpinC1).
Preparation and Storage
This antibody can be stored at 2-8°C for one month without detectable loss of activity.
Antibody products are stable for 12 months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (Final Concentration 0.05% - 0.1%). It is toxic to cells and it should be disposed of properly. Avoid repeated freeze-thaw cycles.
Antibody products are stable for 12 months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (Final Concentration 0.05% - 0.1%). It is toxic to cells and it should be disposed of properly. Avoid repeated freeze-thaw cycles.
Related Product Information for anti-SerpinC1 antibody
SerpinC1, also known as antithrombin III (AT III), is a member of the serpin superfamily of serine protease inhibitors, and has been found to be a marker for disseminated intravascular coagulation (DIC) and to be of prognostic significance in septic patients. SerpinC1 synthesized in the liver is the principal plasma serpin of blood coagulation proteases and inhibits thrombin and other factors such as Xa by the formation of covalently linked complexes. Thus it is one of the most important coagulation inhibitors and the fundamental enzyme for the therapeutical action of heparin. In common with SerpinA5 and D1, the inhibitory activity of SerpinC1 undergoes a dramatic increase in the presence of heparin and other glycosaminoglycans. ATIII mediates the promotion of prostaglandin release, an inhibitor of leucocyte activation and downregulator of many proinflammatory cytokines. Antithrombin III exerts anti-inflammatory properties in addition to its anti-coagulative mechanisms. In animal models of sepsis, ATIII affected cytokine plasma concentrations with a decrease of pro-inflammatory cytokines. The deficiency or functional abnormality of ATIII may result in an increased risk of thromboembolic disease, such as deep vein thrombosis and pulmonary embolism. In addition, it has been reported that SerpinC1 can alter or influence inflammatory processes via inhibition of NF-kappaB activation or actin polymerization.
References
de Sousa JC, et al. (1991) Antithrombin III. Physiologic, physiopathologic and laboratory aspects. Rev Port Cardiol. 10(9): 693-9.Totzke G, et al. (2001) Antithrombin III enhances inducible nitric oxide synthase gene expression in vascular smooth muscle cells. Cell Immunol. 208(1): 1-8.Ostermann H. (2002) Antithrombin III in Sepsis. New evidences and open questions. Minerva Anestesiol. 68(5): 445-8.Caglikulekci M, et al. (2004) Effect of antithrombin-III (AT-III) on intestinal epithelium changes related to obstructive icterus: experimental study in rats. Ann Chir. 129(5): 273-7.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
NCBI Official Full Name
antithrombin-III
NCBI Official Synonym Full Names
serpin peptidase inhibitor, clade C (antithrombin), member 1
NCBI Official Symbol
SERPINC1
NCBI Official Synonym Symbols
AT3; AT3D; ATIII; THPH7
NCBI Protein Information
antithrombin-III; serpin C1; antithrombin III; serine-cysteine proteinase inhibitor clade C member 1; serine (or cysteine) proteinase inhibitor, clade C (antithrombin), member 1
UniProt Protein Name
Antithrombin-III
UniProt Gene Name
SERPINC1
UniProt Synonym Gene Names
AT3; ATIII
UniProt Entry Name
ANT3_HUMAN
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Product Notes
The SerpinC1 serpinc1 (Catalog #AAA254556) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Recombinant Anti-Antithrombin III Antibody, Rabbit Monoclonal reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Antithrombin III can be used in a range of immunoassay formats including, but not limited to, ELISA. Researchers should empirically determine the suitability of the SerpinC1 serpinc1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Antithrombin III, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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