Mouse anti-Human Apolipoprotein A1/APOA1 Monoclonal Antibody | anti-APOA1 antibody

Apolipoprotein A1/APOA1

Cat. Num. AAA215366

• Gene Names: APOA1; HPALP2; apo(a)
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Apolipoprotein A1/APOA1, Antibody; Apolipoprotein A1/APOA1; ApoA1; Brp14; high density lipoprotein uptake; Ltw1; Lvtw1; Sep1; Sep2; anti-APOA1 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: APOA1/3661
• Specificity: Apolipoproteins are protein components of plasma lipoproteins. The human apoA-I gene encodes a single chain, 243 amino acid protein which promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A-I is the major protein component of high density lipoprotein (HDL) in the plasma. It can function as a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for the formation of most plasma cholesteryl esters. The human apoA-II gene encodes the second most abundant protein of HDL particles, where it influences plasma levels of free fatty acids (FFA). The human apoA-IV gene encodes a 396 amino acid preprotein, which after proteolytic processing is secreted from the intestine in association with chylomicron particles. ApoA-IV is a potent activator of LCAT in vitro. The human apoA-V gene encodes a 366 amino acid protein that is believed to be an important determinant of plasma triglyceride levels.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 14

• Applicable Applications for anti-APOA1 antibody: IHC (Immunohistochemistry)
• Immunogen: Human recombinant APOA1 protein fragment (around aa 83-167) (exact sequence is proprietary)
• Cellular Localization: Secreted
• Hu-chromosome Location: 11q23.3
• Positive Control: Human liver
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified Apolipoprotein A1 Mouse Monoclonal Antibody (APOA1/3661). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human liver stained with Apolipoprotein A1 Mouse Monoclonal Antibody (APOA1/3661).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human liver stained with Apolipoprotein A1 Mouse Monoclonal Antibody (APOA1/3661).)

References

Chistiakov DA et al. Lab Invest. 2016 Jul;96(7):708-18.

NCBI and Uniprot Product Information

• NCBI GI #: 553183
• NCBI GeneID: 335
• UniProt Accession #: P02647
• Molecular Weight: 28kDa
• NCBI Official Full Name: APOA1, partial
• NCBI Official Synonym Full Names: apolipoprotein A1
• NCBI Official Symbol: APOA1
• NCBI Official Synonym Symbols: HPALP2; apo(a)
• NCBI Protein Information: apolipoprotein A-I
• UniProt Protein Name: Apolipoprotein A-I
• UniProt Gene Name: APOA1
• UniProt Synonym Gene Names: Apo-AI; ApoA-I
• UniProt Entry Name: APOA1_HUMAN