Rabbit B7-H4 Monoclonal Antibody | anti-B7-H4 antibody

B7-H4 (Immuno-Inhibitory Protein)

Cat. Num. AAA214839

• Gene Names: VTCN1; B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
• Reactivity: Human. Others not known.
• Applications: Immunohistochemistry, ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: B7-H4, Antibody; B7-H4 (Immuno-Inhibitory Protein); B7 family member, H4; B7 homolog 4; B7 superfamily member 1; B7-H4; B7S1; Immune costimulatory protein B7-H4; T-cell costimulatory molecule B7x; V-set domain-containing T-cell activation inhibitor 1; VCTN1; anti-B7-H4 antibody

• Host: Rabbit
• Reactivity: Human. Others not known.
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: B7H4/2652R
• Specificity: T cell activation and immune function are regulated by the innate immune system through positive and negative costimulatory proteins. One such protein, B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 166

• Applicable Applications for anti-B7-H4 antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant human B7-H4 protein fragment (exact sequence is proprietary)
• Positive Control: HeLa or MCF-7 Cells. Ovary, Pancreas, Placenta or Spleen.
• Cellular Localization: Cell Surface & Cytoplasmic
• Chromosome Location: 1p13.1-12
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified B7-H4 Rabbit Recombinant Monoclonal Antibody (B7H4/2652R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Testicular Carcinoma stained with B7-H4 Rabbit Recombinant Monoclonal Antibody (B7H4/2652R).)

Related Product Information for anti-B7-H4 antibody

Recombinant Rabbit Monoclonal Antibody

References

Salceda, S., et al. Exp. Cell Res. 306:128-141.; Sica, G.L., et al. Immunity 18:849-861.

NCBI and Uniprot Product Information

• NCBI GI #: 359718944
• NCBI GeneID: 79679
• NCBI Accession #: NP_001240778.1
• NCBI GenBank Nucleotide #: NM_001253849.1
• UniProt Accession #: Q7Z7D3; Q0GN76; Q45VN0; Q5WPZ3; Q6P097; Q9H6B2
• Molecular Weight: 35kDa
• NCBI Official Full Name: V-set domain-containing T-cell activation inhibitor 1 isoform 2
• NCBI Official Synonym Full Names: V-set domain containing T cell activation inhibitor 1
• NCBI Official Symbol: VTCN1
• NCBI Official Synonym Symbols: B7X; B7H4; B7S1; B7-H4; B7h.5; VCTN1; PRO1291
• NCBI Protein Information: V-set domain-containing T-cell activation inhibitor 1
• UniProt Protein Name: V-set domain-containing T-cell activation inhibitor 1
• UniProt Gene Name: VTCN1
• UniProt Synonym Gene Names: B7-H4