IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human thyroid stained with Calcitonin Mouse Monoclonal Antibody (CALCA/3310). HIER: Tris/EDTA, pH9. 0, 45min. 2 degree : HRP-polymer, 30min. DAB, 5min.)
Mouse anti-Human Calcitonin Monoclonal Antibody | anti-CALCA antibody
Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]
Gene Names
CALCA; CT; KC; CGRP; CALC1; CGRP1; CGRP-I
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
Calcitonin, Antibody; Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310]; Alpha type CGRP; CALC1; calcitonin gene related peptide 1; CT; katacalcin (KC); anti-CALCA antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse/IgG2b, kappa
Clone Number
CALCA/3310
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-CALCA antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant fragment of human Calcitonin protein (around aa 3-116) (exact sequence is proprietary)
Cellular Localization
Cytoplasm, Secreted
Positive Control
Human thyroid.
Hu-chromosome Location
11p15.1
Unigene
37058
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human thyroid stained with Calcitonin Mouse Monoclonal Antibody (CALCA/3310). HIER: Tris/EDTA, pH9. 0, 45min. 2 degree : HRP-polymer, 30min. DAB, 5min.)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human thyroid stained with Calcitonin Mouse Monoclonal Antibody (CALCA/3310). HIER: Tris/EDTA, pH9. 0, 45min. 2 degree : HRP-polymer, 30min. DAB, 5min.)
Related Product Information for anti-CALCA antibody
Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or alpha-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or beta-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
15,466 Da
NCBI Official Full Name
calcitonin isoform CT preproprotein
NCBI Official Synonym Full Names
calcitonin-related polypeptide alpha
NCBI Official Symbol
CALCA
NCBI Official Synonym Symbols
CT; KC; CGRP; CALC1; CGRP1; CGRP-I
NCBI Protein Information
calcitonin; calcitonin gene-related peptide 1; katacalcin; calcitonin 1; alpha-type CGRP; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha
UniProt Protein Name
Calcitonin
UniProt Gene Name
CALCA
UniProt Synonym Gene Names
CALC1; CCP
UniProt Entry Name
CALC_HUMAN
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Product Notes
The CALCA calca (Catalog #AAA215994) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Calcitonin Mouse Monoclonal Antibody [Clone CALCA/3310] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Calcitonin can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CALCA calca for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Calcitonin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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