Mouse anti-Human, Mouse Calregulin Monoclonal Antibody | anti-CALR antibody

Calregulin Monoclonal Antibody

Cat. Num. AAA319978

• Gene Names: CALR; RO; CRT; SSA; cC1qR
• Reactivity: Human, Mouse
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Affinity purification
• Synonyms: Calregulin, Antibody; Calregulin Monoclonal Antibody; Calreticulin; CALR; CRTC; CRP55; Calregulin; Endoplasmic reticulum resident protein 60; ERp60; HACBP; grp60; anti-CALR antibody

• Host: Mouse
• Reactivity: Human, Mouse
• Clonality: Monoclonal
• Specificity: Calregulin Monoclonal Antibody detects endogenous levels of Calregulin protein.
• Purity/Purification: Affinity purification
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applicable Applications for anti-CALR antibody: ELISA, ICC (Immunocytochemistry), IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Synthetic peptide corresponding to aa (EEEDVPGQAKDELC) of human Calreticulin, conjugated to KLH.
• Modification: Unmodified/Total
• Preparation and Storage: Store at -20 degree C/1 year

IF (Immunofluorescence)

(Confocal immunofluorescence analysis of 3T3-L1 cells using Calregulin Monoclonal Antibody (green). Blue: DRAQ5 fluorescent DNA dye.)

IHC (Immunohiostchemistry)

(Immunohistochemistry analysis of paraffin-embedded human placenta tissues with AEC staining using Calregulin Monoclonal Antibody.)

WB (Western Blot)

(Western Blot analysis using Calregulin Monoclonal Antibody against HeLa (1). A549 (2). NTERA2 (3) and MCF-7 (4) cell lysate.)

Related Product Information for anti-CALR antibody

Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its

Product Categories/Family for anti-CALR antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 4757900
• NCBI GeneID: 811
• NCBI Accession #: NP_004334.1
• NCBI GenBank Nucleotide #: NM_004343.3
• UniProt Accession #: P27797; Q6IAT4; Q9UDG2
• Molecular Weight: 48,142 Da
• NCBI Official Full Name: calreticulin
• NCBI Official Synonym Full Names: calreticulin
• NCBI Official Symbol: CALR
• NCBI Official Synonym Symbols: RO; CRT; SSA; cC1qR
• NCBI Protein Information: calreticulin; CRP55; ERp60; HACBP; grp60; calregulin; endoplasmic reticulum resident protein 60; Sicca syndrome antigen A (autoantigen Ro; calreticulin)
• UniProt Protein Name: Calreticulin
• UniProt Gene Name: CALR
• UniProt Synonym Gene Names: CRTC; ERp60
• UniProt Entry Name: CALR_HUMAN