Rat anti-Mouse CD106 Monoclonal Antibody | anti-CD106 antibody
Anti-Ms CD106 Purified Azide Free
Reactivity
Mouse
Applications
Functional Assay, Immunohistochemistry, Immunoprecipitation, Flow Cytometry, Functional Assay
Purity
Purified by protein-A affinity chromatography
Synonyms
CD106, Antibody; Anti-Ms CD106 Purified Azide Free; Vcam-1; vascular cell adhesion molecule 1; anti-CD106 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat IgG2a kappa
Clone Number
429 (MVCAM.A)
Specificity
The rat monoclonal antibody 429 (also known as MVCAM.A) recognizes an extracellular epitope of murine CD106, a 100-110kDa type I membrane protein of the immunoglobulin superfamily, a crucial mediator of leukocyte adhesion, and a costimulation molecule.
Purity/Purification
Purified by protein-A affinity chromatography
Form/Format
Purified Azide Free. Azide free phosphate buffered saline (PBS) solution, 0.2um filter sterilized
Concentration
1mg/ml (varies by lot)
Applicable Applications for anti-CD106 antibody
FA (Functional Assay), IHC (Immunohistochemistry), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry)
Immunogen
Murine preadipose cell line PA6
Preparation and Storage
Store at 2-8 degree C. Do not freeze. Do not use after expiration date stamped on the label.
Related Product Information for anti-CD106 antibody
CD106/VCAM-1 (vascular cell adhesion molecule-1) is an Ig-like cell surface adhesion molecule binding VLA-4 integrin. VCAM-1 is a potent T cell costimulatory molecule taking part in their positive selection and survival, as well as in adhesion, transendothelial migration and activation of peripheral T cells. VCAM-1 is also involved in endothelial cell-cell contacts. Whereas VCAM-1 normally mediates leukocyte extravasion to sites of tissue inflammation, tumour cells can use overexpressed VCAM-1 to escape T cell immunity.
References
*Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ: Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. J Immunol. 2012 Sep 1;189(5):2488-501., URL: https://www.ncbi.nlm.nih.gov/pubmed/22851707,*Dunzendorfer S, Lee HK, Soldau K, Tobias PS: Toll-like receptor 4 Functional Application (FUNC)tions intracellularly in human coronary artery endothelial cells: roles of LBP and sCD14 in mediating LPS responses. FASEB J. 2004 Jul;18(10):1117-9. Epub 2004 May 7., URL: http://www.ncbi.nlm.nih.gov/pubmed/15132988,*Sacher T, Knolle P, Nichterlein T, Arnold B, Hämmerling GJ, Limmer A: CpG-ODN-induced inflammation is sufficient to cause T-cell-mediated autoaggression against hepatocytes. Eur J Immunol. 2002 Dec;32(12):3628-37., URL: https://www.ncbi.nlm.nih.gov/pubmed/12516551
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Product Notes
The CD106 (Catalog #AAA129069) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Anti-Ms CD106 Purified Azide Free reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD106 can be used in a range of immunoassay formats including, but not limited to, FA (Functional Assay), IHC (Immunohistochemistry), IP (Immunoprecipitation), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD106 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD106, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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