Rat anti-Mouse CD11b/Mac-1 Monoclonal Antibody | anti-ATP6V1B2 antibody
Rat Anti-Mouse CD11b/Mac-1a-UNLB
Gene Names
ATP6V1B2; HO57; VATB; VPP3; Vma2; ATP6B2; ATP6B1B2; ATP6V1B2
Reactivity
Mouse
Applications
Flow Cytometry, Functional Assay
Synonyms
CD11b/Mac-1, Antibody; Rat Anti-Mouse CD11b/Mac-1a-UNLB; Rat Anti-Mouse CD11b/Mac-1a - Purified, Unlabeled Antibody; Rat Anti-Mouse CD11b/Mac-1; anti-ATP6V1B2 antibody
Host
Rat
Reactivity
Mouse
Clonality
Monoclonal
Isotype
Rat (Dark Agouti) IgG2bkappa
Clone Number
M1/70
Specificity
Mouse/Human/Rhesus/Baboon/Rabbit CD11b; Mr 170 kDa
Form/Format
Purified (UNLB) Antibody
Sequence Length
1152
Applicable Applications for anti-ATP6V1B2 antibody
FCM/FACS (Flow Cytometry)
Immunogen
C57BL/10 mouse splenic T cells and concanavaline A-activated C57BL/10 splenocytes
Preparation and Storage
Store at 2- 8°C.
The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.
The purified (UNLB) antibody is supplied as 0.5 mg of purified immunoglobulin in 1.0 mL of borate buffered saline, pH 8.2. No preservatives or amine-containing buffer salts added.
Related Product Information for anti-ATP6V1B2 antibody
CD11b, the integrin alphaM subunit, combines with CD18, the integrin B2 subunit, to form the integrin Mac-1, also known as complement receptor 3 (CR3), which mediates adhesion to C3bi and ICAM-1/CD54. Mac-1 is expressed at varying levels on granulocytes, macrophages, dendritic cells, NK cells, and B-1 cells in the peritoneal and pleural cavities. Mac-1 expression is rapidly up-regulated on neutrophils after activation and in the same time period that CD62L is shed from the cell surface. In addition to its role in binding C3bi on opsonized targets and mediation of the subsequent ingestion process, Mac-1 is important as an adhesion molecule in the transendothelial migration of monocytes and neutrophils. Cross-reaction of M1/70 to human CD11b has been observed on monocytes, polymorphonuclear leukocytes, and NK cells.
References
1. Springer, T.A., G. Galfre. D.S. Secher, and C. Milstein. 1978. Eur. J. Immunol. 8:539.
2. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1979. Eur. J. Immunol. 9:301.
3. Springer, T.A., D. Davignon, M.-K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171.
4. Beller, D.I., T.A. Springer, R.D. Schreiber. 1982. J. Exp. Med. 156:1000.
5. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. J. Exp. Med. 158:586.
6. Lub, M., Y. van Kooyk, and C.J. Figdor. 1996. J. Leukoc. Biol. 59:648.
7. Kantor, A.B., A. M. Stall, S. Adams, L.A. Herzenberg, and L.A. Herzenberg. 1992. Proc. Natl. Acad. Sci. USA 89:3320.
8. Ault, K.A., and T.A. Springer. 1981. J. Immunol. 126:359.
9. Gresham, H.D., I.L. Graham, D.C. Anderson, and E.J. Brown. 1991. J. Clin. Invest. 88:588.
10. Springer, T.A. 1994. Cell 76:310.
11. Flotte, T.J., T.A. Springer, and G. Thorbecke. 1983. Am. J. Pathol. 111:112.
12. Gyetko, M.R., S. Sud, T. Kendall, J.A. Fuller, M. W. Newstead, and T.J. Standiford. 2000. J. Immunol. 165:1513.
2. Springer, T., G. Galfre, D.S. Secher, and C. Milstein. 1979. Eur. J. Immunol. 9:301.
3. Springer, T.A., D. Davignon, M.-K. Ho, K. Kurzinger, E. Martz, and F. Sanchez-Madrid. 1982. Immunol. Rev. 68:171.
4. Beller, D.I., T.A. Springer, R.D. Schreiber. 1982. J. Exp. Med. 156:1000.
5. Sanchez-Madrid, F., P. Simon, S. Thompson, and T.A. Springer. 1983. J. Exp. Med. 158:586.
6. Lub, M., Y. van Kooyk, and C.J. Figdor. 1996. J. Leukoc. Biol. 59:648.
7. Kantor, A.B., A. M. Stall, S. Adams, L.A. Herzenberg, and L.A. Herzenberg. 1992. Proc. Natl. Acad. Sci. USA 89:3320.
8. Ault, K.A., and T.A. Springer. 1981. J. Immunol. 126:359.
9. Gresham, H.D., I.L. Graham, D.C. Anderson, and E.J. Brown. 1991. J. Clin. Invest. 88:588.
10. Springer, T.A. 1994. Cell 76:310.
11. Flotte, T.J., T.A. Springer, and G. Thorbecke. 1983. Am. J. Pathol. 111:112.
12. Gyetko, M.R., S. Sud, T. Kendall, J.A. Fuller, M. W. Newstead, and T.J. Standiford. 2000. J. Immunol. 165:1513.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
CD11b
NCBI Official Synonym Full Names
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2
NCBI Official Symbol
ATP6V1B2
NCBI Official Synonym Symbols
HO57; VATB; VPP3; Vma2; ATP6B2; ATP6B1B2; ATP6V1B2
NCBI Protein Information
V-type proton ATPase subunit B, brain isoform; V-ATPase B2 subunit; V-ATPase subunit B 2; vacuolar proton pump subunit B 2; H+ transporting two-sector ATPase; vacuolar H+-ATPase 56,000 subunit; endomembrane proton pump 58 kDa subunit
UniProt Protein Name
V-type proton ATPase subunit B, brain isoform
UniProt Gene Name
ATP6V1B2
UniProt Synonym Gene Names
ATP6B2; VPP3
UniProt Entry Name
VATB2_HUMAN
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Product Notes
The ATP6V1B2 atp6v1b2 (Catalog #AAA78669) is an Antibody produced from Rat and is intended for research purposes only. The product is available for immediate purchase. The Rat Anti-Mouse CD11b/Mac-1a-UNLB reacts with Mouse and may cross-react with other species as described in the data sheet. AAA Biotech's CD11b/Mac-1 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the ATP6V1B2 atp6v1b2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD11b/Mac-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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