Mouse CD11c Monoclonal Antibody | anti-CD11c antibody

MOUSE ANTI HUMAN CD11c:FITC

Cat. Num. AAA50152

• Gene Names: ITGAX; CD11C; SLEB6
• Reactivity: Cynomolgus monkey; N.B. Antibody reactivity and working conditions may vary between species.
• Applications: Flow Cytometry, Functional Assay
• Synonyms: CD11c, Antibody; MOUSE ANTI HUMAN CD11c:FITC; anti-CD11c antibody

• Host: Mouse
• Reactivity: Cynomolgus monkey; N.B. Antibody reactivity and working conditions may vary between species.
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: BU15
• Specificity: Mouse anti Human CD11c antibody, clone Bu15 recognizes the integrin alphax subunit (ITGAX), a ~150 kDa glycoprotein also known as CD11 antigen-like family member C or Leu M5, CD11c is expressed by macrophages, monocytes, NK cells and most dendritic cells (Kohrgruber et al. 1999). CD11c is also expressed at a lower level by granulocytes.; CD11c forms a heterodimeric integral membrane protein with the integrin beta 2 chain to form the leukocyte specific integrin 'inactivated-C3b receptor 4'. CD11c interacts with a number of ligands including the G-P-R sequence in fibrinogen, ICAM-1 (Frick et al. 2005), iC3b (Sadhu et al. 2007) and Junctional adhesion molecule-like (Bazzoni et al. 2011). CD11c is involved in cell-cell interactions during the inflammatory process and is important for monocyte adhesion and chemotaxis. CD11c also acts as a signalling receptor for polysaccharide (Inqualls et al. 1995); CD11c is expressed by hairy cell leukaemia cells (Goodman et al. 2003; Nicolaou et al. 2003).
• Form/Format: Purified IgG conjugated to Fluorescein Isothiocyanate Isomer 1 (FITC) - liquid
• Concentration: IgG concentration 0.1 mg/ml (varies by lot)
• Sequence Length: 1163

• Applicable Applications for anti-CD11c antibody: FCM/FACS (Flow Cytometry)
• Perservative Stabilisers: 0.09% Sodium Azide; 1% Bovine Serum Albumin
• Preparation: Purified IgG prepared from tissue culture supernatant
• Buffer Solution: Phosphate buffered saline.
• Target Species: Human
• Max Ex/Em: Fluorophore: FITC; Excitation Max (nm): 490; Emission Max (nm): 525
• Preparation and Storage: Store at +4°C or at -20°C if preferred.; This product should be stored undiluted.; Storage in frost free freezers is not recommended. This product is photosensitive and should be protected from light.; Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.

NCBI and Uniprot Product Information

• NCBI GI #: 34452173
• NCBI GeneID: 3687
• NCBI Accession #: NP_000878.2
• NCBI GenBank Nucleotide #: NM_000887.4
• UniProt Accession #: P20702; Q8IVA6
• NCBI Official Full Name: integrin alpha-X isoform 2
• NCBI Official Synonym Full Names: integrin, alpha X (complement component 3 receptor 4 subunit)
• NCBI Official Symbol: ITGAX
• NCBI Official Synonym Symbols: CD11C; SLEB6
• NCBI Protein Information: integrin alpha-X; CD11 antigen-like family member C; integrin, alpha X (antigen CD11C (p150), alpha polypeptide); leu M5, alpha subunit; leukocyte adhesion glycoprotein p150,95 alpha chain; leukocyte adhesion receptor p150,95; leukocyte surface antigen p150,95, alpha subunit; myeloid membrane antigen, alpha subunit; p150 95 integrin alpha chain
• UniProt Protein Name: Integrin alpha-X
• UniProt Gene Name: ITGAX
• UniProt Synonym Gene Names: CD11C
• UniProt Entry Name: ITAX_HUMAN