Mouse anti-Human CD137L/4-1BBL/TNFSF9 Monoclonal Antibody | anti-TNFSF9 antibody

CD137L/4-1BBL/TNFSF9

Cat. Num. AAA215273

• Gene Names: TNFSF9; CD137L; TNLG5A; 4-1BB-L
• Reactivity: Human
• Applications: Immunohistochemistry, Flow Cytometry, Functional Assay
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: CD137L/4-1BBL/TNFSF9, Antibody; CD137L/4-1BBL/TNFSF9; 4-1BB ligand; 4-1BBL; CD137L; ILA ligand (TNF related); Ly63l; Tumor necrosis factor ligand 5A (TNLG5A); Tumor necrosis factor ligand superfamily member 9 (TNFSF9); anti-TNFSF9 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2a, kappa
• Clone Number: CD137L/1547
• Specificity: TNFSF9/4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 254

• Applicable Applications for anti-TNFSF9 antibody: IHC (Immunohistochemistry), FCM/FACS (Flow Cytometry)
• Positive Control: Raji, 293T, HEK293 cells. Kidney.
• Immunogen: Recombinant full-length human CD137L protein
• Cellular Localization: Cell Surface and Cytoplasmic
• Hu-chromosome Location: 19p13.3
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

FCM/FACS (Flow Cytometry)

(Flow Cytometric Analysis of PFA-fixed HEK293 cells using CD137L-Monospecific Mouse Monoclonal Antibody (CD137L/1547) followed by goat anti-Mouse IgG-CF488 (Blue); Isotype Control (Red).)

SDS-PAGE

(SDS-PAGE Analysis Purified CD137L-Monospecific Mouse Monoclonal Antibody (CD137L/1547). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with CD137L-Monospecific Mouse Monoclonal Antibody (CD137L/1547).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Renal Cell Carcinoma stained with CD137L-Monospecific Mouse Monoclonal Antibody (CD137L/1547).)

References

1. Zhao S, et al. Am J Surg Pathol, 2013 Feb. PMID 23095505. 2. Qian Y, et al. Med Oncol, 2015 Mar. PMID 25631633

NCBI and Uniprot Product Information

• NCBI GI #: 4507609
• NCBI GeneID: 8744
• NCBI Accession #: NP_003802.1
• NCBI GenBank Nucleotide #: NP_003802.1
• UniProt Accession #: P41273
• Molecular Weight: 27kDa
• NCBI Official Full Name: tumor necrosis factor ligand superfamily member 9
• NCBI Official Synonym Full Names: TNF superfamily member 9
• NCBI Official Symbol: TNFSF9
• NCBI Official Synonym Symbols: CD137L; TNLG5A; 4-1BB-L
• NCBI Protein Information: tumor necrosis factor ligand superfamily member 9
• UniProt Protein Name: Tumor necrosis factor ligand superfamily member 9
• UniProt Gene Name: TNFSF9
• UniProt Synonym Gene Names: 4-1BBL
• UniProt Entry Name: TNFL9_HUMAN