SDS-PAGE
(SDS-PAGE Analysis Purified CD171 Mouse Monoclonal Antibody (UJ127). Confirmation of Integrity and Purity of Antibody.)
Mouse anti-Human. CD171 Monoclonal Antibody | anti-L1CAM antibody
CD171/ NCAM-L1
Gene Names
L1CAM; S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
Reactivity
Human.
Applications
Immunohistochemistry, Western Blot, Immunoprecipitation, Immunofluorescence, Flow Cytometry, Functional Assay, ELISA
Synonyms
CD171, Antibody; CD171/ NCAM-L1; CAML1; HSAS1; Hyd; L1 Cell Adhesion Molecule; L1-NCAM; MASA; MIC5; NCAM-L1; Nerve-growth factor-inducible large external glycoprotein; Neural cell adhesion molecule L1; NILE; S10; SPG1; anti-L1CAM antibody
Host
Mouse
Reactivity
Human.
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
UJ127
Specificity
Recognizes a cell surface protein of 220-240kDa, identified as L1 cell adhesion molecule. The L1CAM gene, which is located in Xq28, is involved in three distinct conditions: 1) HSAS (hydrocephalus-stenosis of the aqueduct of Sylvius); 2) MASA (mental retardation, aphasia, shuffling gait, and adducted thumbs); and 3) SPG1 (spastic paraplegia). The L1, neural cell adhesion molecule (L1CAM) also plays an important role in axon growth, fasciculation, and neural migration as well as in mediating neuronal differentiation. Expression of L1 protein is restricted to tissues arising from neuroectoderm. This MAb is useful in the identification of primitive neuroectodermal tumors. It binds to tumors of neuroectodermal and glial origin e.g. neuroblastoma and Schwannomas. It does not bind to pediatric or adult brain.
Form/Format
200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide.
Sequence Length
1257
Applicable Applications for anti-L1CAM antibody
IHC (Immunohistochemistry), WB (Western Blot), IP (Immunoprecipitation), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA
Localization
Cell surface
Positive Control
Neuroblastomas or Schwannomas
Human Chromosomal Location
Xq28
Immunogen
Homogenous suspension of 16 week human fetal brain
Quantity and Buffer
0.5 ml at 200ug/ml with BSA and azide
Preparation and Storage
Antibody with azide store at 2 to 8°C. Antibody without azide store at -20 to -80°C
SDS-PAGE
(SDS-PAGE Analysis Purified CD171 Mouse Monoclonal Antibody (UJ127). Confirmation of Integrity and Purity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified CD171 Mouse Monoclonal Antibody (UJ127). Confirmation of Integrity and Purity of Antibody.)
References
1. Kemshead J, et. al. International J Cancer, 1983; 31:187-195.
2. Patel, et. al. Biochem Soc Transactions, 1990; 18:274
2. Patel, et. al. Biochem Soc Transactions, 1990; 18:274
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
220-240kDa
NCBI Official Full Name
neural cell adhesion molecule L1 isoform 1
NCBI Official Synonym Full Names
L1 cell adhesion molecule
NCBI Official Symbol
L1CAM
NCBI Official Synonym Symbols
S10; HSAS; MASA; MIC5; SPG1; CAML1; CD171; HSAS1; N-CAML1; NCAM-L1; N-CAM-L1
NCBI Protein Information
neural cell adhesion molecule L1; antigen identified by monoclonal antibody R1
UniProt Protein Name
Neural cell adhesion molecule L1
UniProt Gene Name
L1CAM
UniProt Synonym Gene Names
CAML1; MIC5; N-CAM-L1; NCAM-L1
UniProt Entry Name
L1CAM_HUMAN
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Product Notes
The L1CAM l1cam (Catalog #AAA62589) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The CD171/ NCAM-L1 reacts with Human. and may cross-react with other species as described in the data sheet. AAA Biotech's CD171 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), WB (Western Blot), IP (Immunoprecipitation), IF (Immunofluorescence), FCM/FACS (Flow Cytometry), ELISA. Researchers should empirically determine the suitability of the L1CAM l1cam for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD171, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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