CD22 recombinant antibody
Anti-CD22 [hL22 (Epratuzumab)]
Gene Names
CD22; SIGLEC2; SIGLEC-2
Reactivity
Human, Rhesus Monkey, Cynomolgus Monkey
Applications
Flow Cytometry, Functional Assay, Immunoprecipitation
Purity
Protein A Affinity Purified
Synonyms
CD22, Recombinant Antibody; Anti-CD22 [hL22 (Epratuzumab)]; B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD22 recombinant antibody
Reactivity
Human, Rhesus Monkey, Cynomolgus Monkey
Clonality
Monoclonal
Isotype
Human IgG1, kappa
Clone Number
hL22 (Epratuzumab)
Specificity
This antibody is specific for the 3rd Ig-like domain of human CD22 (epitope B), a cell surface glycoprotein present on mature B-cells and on many types of malignant B-cells
Purity/Purification
Protein A Affinity Purified
Form/Format
PBS with 0.02% Proclin 300.
Concentration
1 mg/ml (varies by lot)
Sequence Length
40
Applicable Applications for CD22 recombinant antibody
FCM/FACS (Flow Cytometry), IP (Immunoprecipitation), Blocking
Immunogen
This antibody was prepared by the humanization of LL2 (EPB-2), a murine anti-CD22 IgG2a raised against Raji Burkitt lymphoma cells. Murine sequences comprise 5-10% of the molecule, with the remainder being human framework sequences, which greatly reduces the potential for immunogenicity (Traczewski, 2010).
Publication Note
Pawlak-Byczkowskaet et al (1989) describes the use of LL2 (EPB-2) in IHC analysis to stain malignant lymphoma tissue sections. Leung et al (1995) describes the generation of a humanized LL2 antibody.
Preparation and Storage
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
Related Product Information for CD22 recombinant antibody
Recombinant monoclonal antibody to CD22. Manufactured using Recombinant Platform with variable regions (i.e. specificity) from the hybridoma hL22 (Epratuzumab).
Product Categories/Family for CD22 recombinant antibody
References
Pawlak-Byczkowska et al., Leung et al. Cancer research, 15 August 1989, Vol.49(16), pp.4568-77 &Molecular Immunology, 1995, Vol.32(17), pp.1413-1427
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
CD22, partial
NCBI Official Synonym Full Names
CD22 molecule
NCBI Official Symbol
CD22
NCBI Official Synonym Symbols
SIGLEC2; SIGLEC-2
NCBI Protein Information
B-cell receptor CD22
UniProt Protein Name
B-cell receptor CD22
UniProt Gene Name
CD22
UniProt Synonym Gene Names
SIGLEC2; BL-CAM; Siglec-2
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Product Notes
The CD22 cd22 (Catalog #AAA71979) is a Recombinant Antibody and is intended for research purposes only. The product is available for immediate purchase. The Anti-CD22 [hL22 (Epratuzumab)] reacts with Human, Rhesus Monkey, Cynomolgus Monkey and may cross-react with other species as described in the data sheet. AAA Biotech's CD22 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), IP (Immunoprecipitation), Blocking. Researchers should empirically determine the suitability of the CD22 cd22 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD22, Monoclonal Recombinant Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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