Mouse anti-Human CD223 (LAG3) Monoclonal Antibody | anti-CD223 antibody
Anti-Human CD223 (LAG3) FITC
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Purity
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Synonyms
CD223 (LAG3), Antibody; Anti-Human CD223 (LAG3) FITC; anti-CD223 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG1, kappa
Clone Number
3DS223H
Purity/Purification
The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Form/Format
Phosphate-buffered aqueous solution, ?0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Concentration
5 uL (0.06 ug)/test (varies by lot)
Applicable Applications for anti-CD223 antibody
FCM/FACS (Flow Cytometry)
Conjugation
FITC
Laser
Blue (488nm)
Peak Emission
520nm
Peak Excitation
494nm
Filter
530/30
Brightness (1=dim,5=brightest)
3
Preparation and Storage
Product should be kept at 2-8°C and protected from prolonged exposure to light.The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Related Product Information for anti-CD223 antibody
The 3DS223H monoclonal antibody recognized human CD223, a 70 kDa glycoprotein that is also known as the Lymphocyte Activation Gene 3 (LAG-3). CD223 is an immune checkpoint receptor in the Ig superfamily and its main ligand is MHC class II, which it binds with higher affinity than CD4. It is reported to play a role in Treg suppressive activity and is involved in the maturation and activation of dendritic cells
References
Anvari, S., Grimbergen, A., Davis, C. M., & Makedonas, G. (2017). Protein transport inhibitors downregulate the expression of LAG-3 on regulatory T cells. Journal of immunological methods, 447, 47-51.
Jiang, Z., Jiang, X., Chen, S., Lai, Y., Wei, X., Li, B.,... & Liu, Q. (2017). Anti-GPC3-CAR T cells suppress the growth of tumor cells in patient-derived xenografts of hepatocellular carcinoma. Frontiers in immunology, 7, 690.
Long, A. H., Highfill, S. L., Cui, Y., Smith, J. P., Walker, A. J., Ramakrishna, S.,... & Mackall, C. L. (2016). Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas. Cancer immunology research, canimm-0230.
Jiang, Z., Jiang, X., Chen, S., Lai, Y., Wei, X., Li, B.,... & Liu, Q. (2017). Anti-GPC3-CAR T cells suppress the growth of tumor cells in patient-derived xenografts of hepatocellular carcinoma. Frontiers in immunology, 7, 690.
Long, A. H., Highfill, S. L., Cui, Y., Smith, J. P., Walker, A. J., Ramakrishna, S.,... & Mackall, C. L. (2016). Reduction of MDSCs with all-trans retinoic acid improves CAR therapy efficacy for sarcomas. Cancer immunology research, canimm-0230.
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Product Notes
The CD223 (Catalog #AAA79342) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Anti-Human CD223 (LAG3) FITC reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CD223 (LAG3) can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the CD223 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD223 (LAG3), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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