Mouse anti-Human CD268 Monoclonal Antibody | anti-CD268 antibody

Anti-Hu CD268 PE

Cat. Num. AAA129151

• Gene Names: TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• Reactivity: Human
• Applications: Flow Cytometry, Functional Assay
• Purity: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Synonyms: CD268, Antibody; Anti-Hu CD268 PE; TNFRSF13C; BAFFR; CVID4; BAFF-R; BROMIX; prolixin; TNF receptor superfamily member 13C; anti-CD268 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse IgG1 kappa
• Clone Number: 11C1
• Specificity: The mouse monoclonal antibody 11C1 recognizes an extracellular epitope of CD268/BAFF R (B cell-activating factor receptor), a 19kDa type III transmembrane protein expressed on resting B cells and CD4-positive T cells, but down regulated after activation.
• Purity/Purification: The purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
• Form/Format: Stabilizing phosphate buffered saline (PBS) solution containing 15mM sodium azide

• Applicable Applications for anti-CD268 antibody: FCM/FACS (Flow Cytometry)
• Conjugation: PE
• Immunogen: human CD268-transfected murine L1.2 cells
• Preparation and Storage: Store in the dark at 2-8 degree C. Do not freeze. Avoid prolonged exposure to light. Do not use after expiration date stamped on vial label.

Related Product Information for anti-CD268 antibody

CD268/BAFF R is a TNFR family receptor that binds the B-cell-activating factor (CD257/BAFF). Splice variants of CD268 have been observed both in man and mouse. A naturally occurring mutation of CD268 in A/WySnJ mice is associated with low number of mature B cells, but with normal B cell precursors. The role of BAFF in B-cell survival and activation make CD268 a potential test reagent. It may be involved in survival of B-cell malignancies. Experimental administration of a CD268-Fc fusion protein suppresses antibody responses. In T cells the CD268 costimulates their activation and proliferation. Defects in CD268 cause the common variable immunodeficiency 4 (CVID4).

References

*Schneppenheim J, Hüttl S, Kruchen A, Fluhrer R, Müller I, Saftig P, Schneppenheim R, Martin CL, Schröder B: Signal-peptide-peptidase-like 2a is required for CD74 intramembrane proteolysis in human B cells. Biochem Biophys Res Commun. 2014 Aug 15;451(1):48-53., URL: http://www.ncbi.nlm.nih.gov/pubmed/term=schneppen,*Yoshimoto K, Tanaka M, Kojima M, Setoyama Y, Kameda H, Suzuki K, Tsuzaka K, Ogawa Y, Tsubota K, Abe T, Takeuchi T: Regulatory mechanisms for the production of BAFF and IL-6 are impaired in monocytes of patients of primary Sjögren's syndrome. Arthritis Res Ther. 2011;13(5):R170., URL: http://www.ncbi.nlm.nih.gov/pubmed/22018243,*Proust A, Rincé P, Creidy R, Lazure T, Joab I, Garçon L, Fabre M, Guettier C, Raphael M: p52 Activation in monomorphic B-cell posttransplant lymphoproliferative disorder/diffuse large B-cell lymphoma without BAFF-R expression. Am J Pathol. 2011 Oct;179(4):1630-7., URL: http://www.ncbi.nlm.nih.gov/pubmed/term=proust+a+

NCBI and Uniprot Product Information

• NCBI GI #: 85567349
• NCBI GeneID: 115650
• UniProt Accession #: Q96RJ3
• Molecular Weight: 18,864 Da
• NCBI Official Full Name: BAFF receptor
• NCBI Official Synonym Full Names: tumor necrosis factor receptor superfamily, member 13C
• NCBI Official Symbol: TNFRSF13C
• NCBI Official Synonym Symbols: BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin
• NCBI Protein Information: tumor necrosis factor receptor superfamily member 13C; BAFF receptor; BLyS receptor 3; B cell-activating factor receptor; B-cell-activating factor receptor
• UniProt Protein Name: Tumor necrosis factor receptor superfamily member 13C
• UniProt Gene Name: TNFRSF13C
• UniProt Synonym Gene Names: BAFFR; BR3; BAFF-R
• UniProt Entry Name: TR13C_HUMAN