Rabbit anti-Human CD99/MIC2 Monoclonal Antibody | anti-CD99 antibody

CD99/MIC2 (Ewing s Sarcoma Marker) Recombinant Rabbit Monoclonal Antibody [Clone MIC2/3478R]

Cat. Num. AAA215804

• Gene Names: CD99; MIC2; HBA71; MIC2X; MIC2Y; MSK5X
• Reactivity: Human
• Applications: Immunohistochemistry
• Synonyms: CD99/MIC2, Antibody; CD99/MIC2 (Ewing s Sarcoma Marker) Recombinant Rabbit Monoclonal Antibody [Clone MIC2/3478R]; CD99/MIC2 (Ewing s Sarcoma Marker); 12E7; E2 antigen; MIC 2X; MIC 2Y; MIC2; Protein MIC2; Surface antigen MIC2; T-cell surface glycoprotein E2; anti-CD99 antibody

• Host: Rabbit
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Rabbit/IgG
• Clone Number: MIC2/3478R
• Form/Format: 200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Concentration: Purified Ab with BSA and Azide at 200ug/ml; OR; Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)

• Applicable Applications for anti-CD99 antibody: IHC (Immunohistochemistry)
• Antibody Type: Recombinant Antibody
• Immunogen: Synthetic peptide corresponding to CD99 residues within aa85 C terminal of CD99 was used as an immunogen.
• Cellular Localization: Cell Surface
• Positive Control: MOLT-4 cells. Pancreas or Ewing s sarcoma
• Hu-chromosome Location: Xp22.33
• Unigene: 653349
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Ewing's Sarcoma stained with CD99 Rabbit Recombinant Monoclonal Antibody (MIC2/3478R).)

Related Product Information for anti-CD99 antibody

CD99 is a type I transmembrane glycoprotein encoded by the CD99 gene and the functions of CD99 in cells in which CD99 was highly expressed have been studied and they were as follows: cell death of thymocytes and T lymphocytes, migration through monocyte endothelial junctions by adhesion and diapedesis, cell-cell adhesion in lymphocytes, maintenance of cellular morphology in Hodgkin and Reed/Sternberg cells, and recruitment of T cells. CD99 expression has been reported in many cell types, such as hematopoietic cells, endothelial cells, central nervous system ependymal cells, thymocytes, granular cells of the ovary, Sertoli cells, and pancreatic islet cells. And in tumors it expressed by virtually almost all Ewing s sarcoma and primitive peripheral neuroectodermal tumors (ES/PNET) and demonstrates strong and diffuse membranous staining. Other tumors that may show CD99 expression include neuroendocrine carcinomas, mesenchymal chondrosarcomas, solitary fibrous tumors, synovial sarcomas, vascular tumors, small round blue cell tumors, lymphoblastic lymphoma, acute myeloid leukemia, and myeloid sarcoma. Studies have shown that CD99 may be a sensitive marker for Ewing s sarcoma and peripheral neuroectodermal tumors.

NCBI and Uniprot Product Information

• NCBI GI #: 4505183
• NCBI GeneID: 4267
• NCBI Accession #: NP_002405.1
• NCBI GenBank Nucleotide #: NM_002414.3
• UniProt Accession #: P14209; O00518; Q6ICV7; A6NIW1
• Molecular Weight: 18,848 Da
• NCBI Official Full Name: CD99 antigen isoform a
• NCBI Official Synonym Full Names: CD99 molecule
• NCBI Official Symbol: CD99
• NCBI Official Synonym Symbols: MIC2; HBA71; MIC2X; MIC2Y; MSK5X
• NCBI Protein Information: CD99 antigen; E2 antigen; surface antigen MIC2; T-cell surface glycoprotein E2; MIC2 (monoclonal antibody 12E7); antigen identified by monoclonal 12E7, Y homolog; antigen identified by monoclonal antibodies 12E7, F21 and O13
• UniProt Protein Name: CD99 antigen
• UniProt Gene Name: CD99
• UniProt Synonym Gene Names: MIC2; MIC2X; MIC2Y
• UniProt Entry Name: CD99_HUMAN