Rabbit CDX2 Monoclonal Antibody | anti-CDX2 antibody

CDX2 (GI Epithelial Marker)

Cat. Num. AAA214719

• Gene Names: CDX2; CDX3; CDX-3; CDX2/AS
• Reactivity: Human. Others not known.
• Applications: Immunohistochemistry, ELISA
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: CDX2, Antibody; CDX2 (GI Epithelial Marker); Caudal type homeobox 2; Caudal type homeobox transcription factor 2; Caudal-type homeobox protein 2; CDX2; anti-CDX2 antibody

• Host: Rabbit
• Reactivity: Human. Others not known.
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: CDX2/2951R
• Specificity: The intestine-specific transcription factors CDX1 and CDX2 are important for directing intestinal development, differentiation, proliferation and maintenance of the intestinal phenotype. CDX2 protein expression has been seen in GI carcinomas. Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 313

• Applicable Applications for anti-CDX2 antibody: IHC (Immunohistochemistry), ELISA
• Immunogen: Recombinant fragment (around aa150-249) of human CDX2 protein (exact sequence is proprietary)
• Positive Control: HT29 Cells or Colon Carcinoma
• Cellular Localization: Nuclear
• Chromosome Location: 13q12.2
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R).)

SDS-PAGE

(SDS-PAGE Analysis Purified CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Colon Carcinoma stained with CDX2 Rabbit Recombinant Monoclonal Antibody (CDX2/2951R).)

Related Product Information for anti-CDX2 antibody

Recombinant Rabbit Monoclonal Antibody

References

Silberg, D.G., et al. 2000. Gastroenterology 119: 961-971.; Mallo, G.V., et al. 1998. J. Biol. Chem. 273: 14030-14036.

NCBI and Uniprot Product Information

• NCBI GI #: 372624392
• NCBI GeneID: 1045
• NCBI Accession #: NP_001256.3
• NCBI GenBank Nucleotide #: NM_001265.5
• UniProt Accession #: Q99626; O00503; Q5VTU7; Q969L8; Q9UD92
• Molecular Weight: 40kDa
• NCBI Official Full Name: homeobox protein CDX-2 isoform 1
• NCBI Official Synonym Full Names: caudal type homeobox 2
• NCBI Official Symbol: CDX2
• NCBI Official Synonym Symbols: CDX3; CDX-3; CDX2/AS
• NCBI Protein Information: homeobox protein CDX-2
• UniProt Protein Name: Homeobox protein CDX-2
• UniProt Gene Name: CDX2
• UniProt Synonym Gene Names: CDX3