Mouse Chromogranin A / CHGA Monoclonal Antibody | anti-CHGA antibody

Chromogranin A / CHGA (Neuroendocrine Marker) Mouse Monoclonal Antibody

Cat. Num. AAA62559

• Gene Names: CHGA; CGA
• Reactivity: Human, Monkey, Pig, Mouse, Rat.; Does not react with Guinea Pig, Sheep and Rabbit
• Applications: Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: Chromogranin A / CHGA, Antibody; Chromogranin A / CHGA (Neuroendocrine Marker) Mouse Monoclonal Antibody; Beta-Granin; CGA; CHGA; Chromogranin A Parathyroid Secretory Protein 1; ER-37; Pancreastatin; Parastatin; Parathyroid Secretory Protein 1; Pituitary Secretory Protein I; SP-I; Vasostatin I or II; anti-CHGA antibody

• Host: Mouse
• Reactivity: Human, Monkey, Pig, Mouse, Rat.; Does not react with Guinea Pig, Sheep and Rabbit
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: LK2H10
• Specificity: Chromogranin A is present in neuroendocrine cells throughout the body, including the neuroendocrine cells of the large and small intestine, adrenal medulla and pancreatic islets. It is an excellent marker for carcinoid tumors, pheochromocytomas, paragangliomas, and other neuroendocrine tumors. Co-expression of chromogranin A and neuron specific enolase (NSE) is common in neuroendocrine neoplasms. Reportedly, co-expression of certain keratins and chromogranin indicates neuroendocrine lineage. The presence of strong anti-chromogranin staining and absence of anti-keratin staining should raise the possibility of paraganglioma. The co-expression of chromogranin and NSE is typical of neuroendocrine neoplasms. Most pituitary adenomas and prolactinomas readily express chromogranin.
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 457

• Applicable Applications for anti-CHGA antibody: IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
• Cellular Localization: Finely granular Cytoplasmic
• Immunogen: Human pheochromocytoma
• Hu-Chromosome Location: 14q32.12
• Positive Control: PC12 cells. Adrenal gland, bowel, thyroid, pancreas, or pheochromocytoma.
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C. Non-hazardous. No MSDS required.

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Small Cell Lung Carcinoma stained with Chromogranin A Monoclonal Antibody (LK2H10))

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Adrenal Gland stained with Chromogranin A Monoclonal Antibody (LK2H10))

References

Bruke, et. al. Am J Surg Pathol 13: 828, 1989. Delagi, et. al. Mol Cell Probe 3: 87, 1989. Lloyd RV, et. al. Science, 1983, 222:628-30.

NCBI and Uniprot Product Information

• NCBI GI #: 4502805
• NCBI GeneID: 1113
• NCBI Accession #: NP_001266.1
• NCBI GenBank Nucleotide #: NM_001275.3
• UniProt Accession #: P10645; Q53FA8; Q6NR84; Q96E84; Q96GL7; Q9BQB5; B2R9E9
• Molecular Weight: 68-75kDa
• NCBI Official Full Name: chromogranin-A isoform 1 preproprotein
• NCBI Official Synonym Full Names: chromogranin A
• NCBI Official Symbol: CHGA
• NCBI Official Synonym Symbols: CGA
• NCBI Protein Information: chromogranin-A
• UniProt Protein Name: Chromogranin-A
• UniProt Gene Name: CHGA
• UniProt Synonym Gene Names: CgA; SP-I
• UniProt Entry Name: CMGA_HUMAN