Mouse anti-Human CK19 / CYFRA21-1 Monoclonal Antibody | anti-CK19 / CYFRA21-1 antibody
Monoclonal Anti-CK19 / CYFRA21-1 (Capture Ab)
Reactivity
Human
Applications
ELISA, Western Blot
Purity
>95% by HPLC & SDS-PAGEProtein A or G purified and supplied in 0.01 M PBS (pH7.4) & 0.15 M NaCl without preservative.
Synonyms
CK19 / CYFRA21-1, Antibody; Monoclonal Anti-CK19 / CYFRA21-1 (Capture Ab); anti-CK19 / CYFRA21-1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
D5
Specificity
It specifically recognizes the human CK19 / CYFRA21-1, and may cross react with CK20, CK8 & CK18.
Purity/Purification
>95% by HPLC & SDS-PAGE
Protein A or G purified and supplied in 0.01 M PBS (pH7.4) & 0.15 M NaCl without preservative.
Protein A or G purified and supplied in 0.01 M PBS (pH7.4) & 0.15 M NaCl without preservative.
Form/Format
Liquid
Applicable Applications for anti-CK19 / CYFRA21-1 antibody
CLIA (Chemiluminescence Immunoassay), ELISA, WB (Western Blot)
Immunogen
40 KDa of Keratin 19 protein.
Preparation and Storage
Aliquot and store at -20°C for long term (at least one year).
Avoid repeated freeze and thaw cycles.
Avoid repeated freeze and thaw cycles.
Related Product Information for anti-CK19 / CYFRA21-1 antibody
Keratin, type I cytoskeletal 19 also known as cytokeratin-19 (CK-19) or keratin-19 (K19) is a 40 kDa protein that in humans is encoded by the KRT19 gene. KRT19 is also known as Cyfra 21-1. The usefulness of serum CYFRA 21-1 (cytokeratin-19 fragments) in monitoring the recurrence of breast cancer and in evaluating therapeutic effects. Serum CYFRA 21-1 may be a reliable marker of recurrence or therapeutic efficacy. The serum level of Cyfra21-1 was a useful biomarker for identification of nonsmall cell lung cancer (NSCLC) as well. The serum cytokeratin 19 fragment 21.1 (CYFRA21-1) level was elevated in nasopharyngeal carcinoma (NPC) and can function as a biomarker for detection and monitoring of NPC. After analyzing NPC group and healthy control group, Song XM et al concluded that the serum CYFRA21-1 level could be a reliable and effective biomarker for the detection and monitoring of NPC tumor progression.
References
1. Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol 174 (2): 169–74.
2. Nakata B, Takashima T, Ogawa Y, Ishikawa T, Hirakawa K. Serum CYFRA 21-1 (cytokeratin-19 fragments) is a useful tumour marker for detecting disease relapse and assessing treatment efficacy in breast cancer. Br J Cancer. 2004 Aug 31;91(5):873-8.
3. Cui C, Sun X, Zhang J, Han D, Gu J. The value of serum Cyfra21-1 as a biomarker in the diagnosis of patients with non-small cell lung cancer: a meta-analysis. J Cancer Res Ther. 2014 Nov;10 Suppl:C131-4.
4. Song XM, Wang SZ, Wang ZJ, Cao WJ, L J, Chen F. Serum CYFRA21-1 as an effective tumor biomarker for patients with nasopharyngeal carcinoma. Neoplasma. 2015;62(1):124-9.
2. Nakata B, Takashima T, Ogawa Y, Ishikawa T, Hirakawa K. Serum CYFRA 21-1 (cytokeratin-19 fragments) is a useful tumour marker for detecting disease relapse and assessing treatment efficacy in breast cancer. Br J Cancer. 2004 Aug 31;91(5):873-8.
3. Cui C, Sun X, Zhang J, Han D, Gu J. The value of serum Cyfra21-1 as a biomarker in the diagnosis of patients with non-small cell lung cancer: a meta-analysis. J Cancer Res Ther. 2014 Nov;10 Suppl:C131-4.
4. Song XM, Wang SZ, Wang ZJ, Cao WJ, L J, Chen F. Serum CYFRA21-1 as an effective tumor biomarker for patients with nasopharyngeal carcinoma. Neoplasma. 2015;62(1):124-9.
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Product Notes
The CK19 / CYFRA21-1 (Catalog #AAA59100) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Monoclonal Anti-CK19 / CYFRA21-1 (Capture Ab) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's CK19 / CYFRA21-1 can be used in a range of immunoassay formats including, but not limited to, CLIA (Chemiluminescence Immunoassay), ELISA, WB (Western Blot). Researchers should empirically determine the suitability of the CK19 / CYFRA21-1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CK19 / CYFRA21-1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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