IHC (Immunohiostchemistry)
(Human colon tissue was stained with Anti-Claudin 7 Antibody.)
Mouse Claudin 7 Monoclonal Antibody | anti-CLDN7 antibody
Claudin 7 (ABT-CLD7) Mouse mAb
Gene Names
CLDN7; CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1
Reactivity
Human, Mouse, Rat
Applications
ELISA, Immunofluorescence, Western Blot, Immunohistochemistry
Purity
Purification Method: Protein G
Synonyms
Claudin 7, Antibody; Claudin 7 (ABT-CLD7) Mouse mAb; CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1; anti-CLDN7 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG2a, kappa
Specificity
The antibody can specifically recognize human Claudin 7 protein. In Western blotting of LnCap cell lysate, the antibody can label a 22 kDa band corresponding to Claudin 7.
Purity/Purification
Purification Method: Protein G
Form/Format
PBS, 50% glycerol, 0.05% Proclin 300, 0.05% BSA
Sequence Length
211
Applicable Applications for anti-CLDN7 antibody
ELISA, IF (Immunofluorescence), WB (Western Blot), IHC (Immunohistochemistry)
Immunogen
Synthesized peptide derived from human Claudin 7
AA Range
100-211
Subcellular Location
Membranous
Expression
kindey
Function
Plays a major role in tight junction-specific obliteration of the intercellular space.,induction:By androgens.,similarity:Belongs to the claudin family.,subunit:Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.,tissue specificity:Expressed in kidney, lung and prostate. Isoform 1 seems to be predominant, except in some normal prostate samples, where isoform 2 is the major form. Down-regulated in breast cancers, including ductal carcinoma in situ (DCIS), lobular carcinoma in situ (LCIS) and invasive ductal carcinoma (IDC) (at protein level), as well as in several cancer cell lines. Loss of expression correlates with histological grade, occurring predominantly in high-grade lesions.
Preparation and Storage
Store at -15 degrees C to -25 degrees C/1 year(Do not lower than -25 degrees C)
IHC (Immunohiostchemistry)
(Human colon tissue was stained with Anti-Claudin 7 Antibody.)
IHC (Immunohiostchemistry)
(Human colon tissue was stained with Anti-Claudin 7 Antibody.)
SDS-PAGE
(MCF7 whole cell lysates were separated by 12% SDS-PAGE, and the membrane was blotted with anti-Claudin 7 antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.)
SDS-PAGE
(MCF7 whole cell lysates were separated by 12% SDS-PAGE, and the membrane was blotted with anti-Claudin 7 antibody. The HRP-conjugated Goat anti-Mouse IgG(H + L) antibody was used to detect the antibody.)
Related Product Information for anti-CLDN7 antibody
Background:Claudin 7 is a 22 kDa membrane protein, belonging to the tight junction protein family.Claudin family proteins play an important role in cell polarity, signal transduction and the pathogenesis of a variety of malignant tumors. It has been reported that compared with non neoplastic mucosal tissues,the expression of claudin 7 in laryngeal squamous cell carcinoma is down-regulated, and the expression level is related to distant metastasis, which can be used as a potential predictor of poor prognosis.Therefore, claudin 7 may be a useful immunohistochemical marker for the identification, metastasis and prognosis of laryngeal cancer.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
Molecular Weight(Da):22kD
Observed Band(KD):22kD
Observed Band(KD):22kD
NCBI Official Full Name
claudin-7 isoform 1
NCBI Official Synonym Full Names
claudin 7
NCBI Official Symbol
CLDN7
NCBI Official Synonym Symbols
CLDN-7; CEPTRL2; CPETRL2; Hs.84359; claudin-1
NCBI Protein Information
claudin-7
UniProt Protein Name
Claudin-7
UniProt Gene Name
CLDN7
UniProt Synonym Gene Names
CEPTRL2; CPETRL2; CLDN-7
UniProt Entry Name
CLD7_HUMAN
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Product Notes
The CLDN7 cldn7 (Catalog #AAA268575) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Claudin 7 (ABT-CLD7) Mouse mAb reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's Claudin 7 can be used in a range of immunoassay formats including, but not limited to, ELISA, IF (Immunofluorescence), WB (Western Blot), IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the CLDN7 cldn7 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Claudin 7, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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