Rabbit Cytokeratin 15 (KRT15) Monoclonal Antibody | anti-KRT15 antibody

Cytokeratin 15 (KRT15) (Basal Cell Marker)

Cat. Num. AAA214425

• Gene Names: KRT15; K15; CK15; K1CO
• Reactivity: Human, Rat, Cow. Others not known.
• Applications: Immunohistochemistry
• Synonyms: Cytokeratin 15 (KRT15), Antibody; Cytokeratin 15 (KRT15) (Basal Cell Marker); CK15; Cytokeratin 15; K1CO; Ka15; Keratin 15 basic; Keratin 15 beta; Keratin complex 1 acidic gene 15; Keratin type I cytoskeletal 15; KRT15; KRTB; KRTL15; Type I cytoskeletal 15; Type I keratin Ka15; anti-KRT15 antibody

• Host: Rabbit
• Reactivity: Human, Rat, Cow. Others not known.
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: KRT15/2103R
• Specificity: Keratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I keratin (keratins 9 to 23) and one type II keratin (keratins 1 to 8). Keratins demonstrate tissue and differentiation specific expression profiles. Keratin 15 is a type I keratin which is expressed only in basal keratinocytes in stratified epithelia and does not appear to have a natural type II expression partner. Keratin 15 is down regulated in activated keratinocytes. Cytokeratin 15 is a specific marker of stem cells of the hair-follicle bulge and may be a useful marker for between basal cell carcinoma (BCC) and trichoepithelioma. Trichoblastoma are benign neoplasms of follicular differentiation frequently found in nevus sebaceous. Many morphologic features are shared with nodular basal cell carcinoma, sometimes rendering a difficult. Trichoblastoma and BCC show variable expression of Cytokeratin 15 and Cytokeratin 19, and absence of hair keratins.
• Form/Format: 200ug/ml of Ab purified by Protein A Column. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 456

• Applicable Applications for anti-KRT15 antibody: IHC (Immunohistochemistry)
• Immunogen: Recombinant full-length of human KRT15 protein
• Cellular Localization: Cytoplasmic
• Hu-chromosome Location: 17q21.2
• Positive Control: A431 cells. Skin or Colon
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified Cytokeratin 15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R).)

IHC (Immunohiostchemistry)

(Formalin-fixed, paraffin-embedded human Prostate stained with Cytokeratin 15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R).)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Skin stained with Cytokeratin 15 Rabbit Recombinant Monoclonal Ab (KRT15/2103R).)

References

Porter et al. 2000. Lab Invest. 80(11):1701-10. Inoue et al. 2009. Lab Invest. 89(8):844-56.

NCBI and Uniprot Product Information

• NCBI GI #: 24430190
• NCBI GeneID: 3866
• NCBI Accession #: NP_002266.2
• NCBI GenBank Nucleotide #: NM_002275.3
• UniProt Accession #: P19012; Q53XV8; Q9BUG4; B3KQY1; B3KRA2; E0CX14
• Molecular Weight: 52kDa
• NCBI Official Full Name: keratin, type I cytoskeletal 15
• NCBI Official Synonym Full Names: keratin 15
• NCBI Official Symbol: KRT15
• NCBI Official Synonym Symbols: K15; CK15; K1CO
• NCBI Protein Information: keratin, type I cytoskeletal 15
• UniProt Protein Name: Keratin, type I cytoskeletal 15
• UniProt Gene Name: KRT15
• UniProt Synonym Gene Names: KRTB; CK-15; K15