Mouse anti-Human Cytokeratin 16 (KRT16) Monoclonal Antibody | anti-KRT16 antibody

Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker)

Cat. Num. AAA215065

• Gene Names: KRT16; K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Cytokeratin 16 (KRT16), Antibody; Cytokeratin 16 (KRT16) (Suprabasal Keratinocyte Marker); CK16; Cytokeratin-16; Focal non epidermolytic palmoplantar keratoderma (FNEPPK/NEPPK); K1CP; Keratin Type I Cytoskeletal 16; Keratin-16; KRT16A; anti-KRT16 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: LL025
• Specificity: Cytokeratins are a family of intermediate filament proteins that assemble into filaments through forming heterodimers of one type I Cytokeratins (Cytokeratins 9 to 23) and one type II Cytokeratins (keratins 1 to 8). The cytokeratin proteins play a critical role in differentiation, as well as tissue specialization and function, to maintain the overall structural integrity of epithelial cells. Cytokeratins are also useful markers in identifying the origin of metastatic tumors. Cytokeratin 16 is expressed in benign stratified squamous epithelium and squamous cell carcinoma of the head and neck, as well as luminal cells of mammary gland and sweat ducts. It is absent in non-invasive breast carcinomas and normal breast tissue.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 473

• Applicable Applications for anti-KRT16 antibody: IHC (Immunohistochemistry)
• Positive Control: HeLa cells. Tonsil, Skin. Bladder or Cervix.
• Immunogen: A synthetic peptide from the C-terminal of human Cytokeratin 16
• Cellular Localization: Cytoplasmic
• Hu-chromosome Location: 17q21.2
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified Cytokeratin 16 Mouse Monoclonal Antibody (LL025). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with Cytokeratin 16 Mouse Monoclonal Antibody (LL025).)

References

1. Porter et al. 2000. Lab Invest. 80(11):1701-10. 2. Wetzels et al. 1991. Am J Pathol. 138(3):751-63. 3. Markey et al. 1992. Br J Dermatol. 126(2):154-60.

NCBI and Uniprot Product Information

• NCBI GI #: 24430192
• NCBI GeneID: 3868
• NCBI Accession #: NP_005548.2
• NCBI GenBank Nucleotide #: NP_005548.2
• UniProt Accession #: P08779
• Molecular Weight: 48kDa
• NCBI Official Full Name: keratin, type I cytoskeletal 16
• NCBI Official Synonym Full Names: keratin 16
• NCBI Official Symbol: KRT16
• NCBI Official Synonym Symbols: K16; PC1; CK16; K1CP; NEPPK; FNEPPK; KRT16A
• NCBI Protein Information: keratin, type I cytoskeletal 16
• UniProt Protein Name: Keratin, type I cytoskeletal 16
• UniProt Gene Name: KRT16
• UniProt Synonym Gene Names: KRT16A; CK-16; K16
• UniProt Entry Name: K1C16_HUMAN