Application Data
(Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and ErbB-4 transfected (solid orange histogram) NIH/3T3 cells. Dotted pink histogram represents the isotype control, normal mouse IgG2a.)
Mouse HER4/ErbB4 Monoclonal Antibody | anti-HER4/ErbB4 antibody
HER4/ErbB4 Antibody
Gene Names
ERBB4; HER4; p180erbB4
Reactivity
Human, Mouse, Rat
Applications
Flow Cytometry, Functional Assay, Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Purity
ProA affinity purified
Synonyms
HER4/ErbB4, Antibody; HER4/ErbB4 Antibody; 4ICD antibody; ALS19 antibody; Avian erythroblastic leukemia viral oncogene homolog 4 antibody; Avian erythroblastic leukemia viral v erb b2 oncogene homolog 4 antibody; E4ICD antibody; EC 2.7.10.1 antibody; Erbb4 antibody; ERBB4 intracellular domain antibody; ERBB4_HUMAN antibody; HER 4 antibody; HER4 antibody; human epidermal growth factor receptor 4 antibody; Mer4 antibody; MGC138404 antibody; Oncogene ERBB4 antibody; p180erbB4 antibody; Proto-oncogene-like protein c-ErbB-4 antibody; Receptor protein tyrosine kinase erbB 4 precursor antibody; Receptor tyrosine protein kinase erbB 4 antibody; s80HER4 antibody; Tyrosine kinase type cell surface receptor HER4 antibody; Tyrosine kinase-type cell surface receptor HER4 antibody; v erb a avian erythroblastic leukemia viral oncogene homolog like 4 antibody; v erb a erythroblastic leukemia viral oncogene homolog 4 antibody; v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian) antibody; V-ERB-B2 avian erythroblastic leukemia viral oncogene homolog 4 antibody; Verba avian erythroblastic leukemia viral oncogene homolog like 4 antibody; Verba erythroblastic leukemia viral oncogene homolog 4 antibody; VERBB2 antibody; anti-HER4/ErbB4 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Clone Number
4G19
Purity/Purification
ProA affinity purified
Form/Format
1*TBS (pH7.4), 1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Applicable Applications for anti-HER4/ErbB4 antibody
FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), IF (Immunofluorescence), IP (Immunoprecipitation), WB (Western Blot)
Immunogen
Amino acids 1280-1308 at C-terminus of ErbB-4 of human origin.
Conjugation
Unconjugated
Preparation and Storage
Store at -20 degree C.
Application Data
(Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and ErbB-4 transfected (solid orange histogram) NIH/3T3 cells. Dotted pink histogram represents the isotype control, normal mouse IgG2a.)
Application Data
(Intracellular FCM analysis of fixed and permeabilized control (green line histogram) and ErbB-4 transfected (solid orange histogram) NIH/3T3 cells. Dotted pink histogram represents the isotype control, normal mouse IgG2a.)
WB (Western Blot)
(Western blot analysis of ErbB-4 expression in control (A) and ErbB-4 transfected (B) NIH/3T3 whole cell lysates.)
WB (Western Blot)
(Western blot analysis of ErbB-4 expression in control (A) and ErbB-4 transfected (B) NIH/3T3 whole cell lysates.)
Related Product Information for anti-HER4/ErbB4 antibody
The EGF receptor family comprises several related receptor tyrosine kinases that are frequently overexpressed in a variety of carcinomas. Members of this receptor family include EGFR (HER1), Neu (ErbB-2, HER2), ErbB-3 (HER3) and ErbB-4 (HER4), which form either homodimers or heterodimers upon ligand binding. The gene encoding ErbB-4 is expressed as a full length protein, which produces a short membrane-anchored cytoplasmic domain fragment and a long ectodomain fragment. The short fragment is heavily tyrosine phosphorylated and possesses tyrosine kinase catalytic activity toward an exogenous substrate. Proteolytic cleavage of ErbB-4 is promoted by the binding of heregulin. ErbB-4 is involved in cell proliferation and differentiation and its expression is highest in breast carcinoma cell lines, normal skeletal muscle, heart, pituitary, brain and cerebellum.
Product Categories/Family for anti-HER4/ErbB4 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
146,808 Da
NCBI Official Full Name
receptor tyrosine-protein kinase erbB-4 isoform JM-a/CVT-2
NCBI Official Synonym Full Names
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
NCBI Official Symbol
ERBB4
NCBI Official Synonym Symbols
HER4; p180erbB4
NCBI Protein Information
receptor tyrosine-protein kinase erbB-4; proto-oncogene-like protein c-ErbB-4; tyrosine kinase-type cell surface receptor HER4; avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4
UniProt Protein Name
Receptor tyrosine-protein kinase erbB-4
UniProt Gene Name
ERBB4
UniProt Synonym Gene Names
HER4; 4ICD; E4ICD
UniProt Entry Name
ERBB4_HUMAN
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Product Notes
The HER4/ErbB4 erbb4 (Catalog #AAA311987) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The HER4/ErbB4 Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's HER4/ErbB4 can be used in a range of immunoassay formats including, but not limited to, FCM/FACS (Flow Cytometry), IHC (Immunohistochemistry), IF (Immunofluorescence), IP (Immunoprecipitation), WB (Western Blot). Researchers should empirically determine the suitability of the HER4/ErbB4 erbb4 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "HER4/ErbB4, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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