Rabbit IgM (Immunoglobulin Mu Heavy Chain) Monoclonal Antibody | anti-IgM antibody

IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker)

Cat. Num. AAA214763

• Gene Names: IGHM; MU; VH; AGM1
• Reactivity: Human. Others not known.
• Applications: Immunohistochemistry, Immunofluorescence, Flow Cytometry, Functional Assay
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: IgM (Immunoglobulin Mu Heavy Chain), Antibody; IgM (Immunoglobulin Mu Heavy Chain) (B-Cell Marker); AGM1; IGHM; Constant Region of Heavy Chain of IgM; Ig Mu Chain C Region; anti-IgM antibody

• Host: Rabbit
• Reactivity: Human. Others not known.
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: IGHM/2559R
• Specificity: Recognizes a protein of 75kDa, identified as mu heavy chain of human immunoglobulins. It does not cross-react with alpha (IgA), gamma (IgG), epsilon (IgE), or delta (IgD), heavy chains, T-cells, monocytes, granulocytes, or erythrocytes. Monomeric IgM is expressed as a membrane bound antibody on the surface of B cells and as a pentamer when secreted by plasma cells. IgM antibody is prominent in early immune responses to most antigens. Aberrant levels are associated with immune deficiency states, hereditary deficiencies, myeloma, Waldenstrom's macroglobulinemia, chronic infection and hepatocellular disease. This MAb is useful in the identification of leukemias, plasmacytomas, and certain non-Hodgkin s lymphomas. The most common feature of these malignancies is the restricted expression of a single heavy chain class. Demonstration of clonality in lymphoid infiltrates indicates that the infiltrate is clonal and therefore malignant.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 474

• Applicable Applications for anti-IgM antibody: IHC (Immunohistochemistry), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
• Immunogen: Heavy chain of human IgM
• Positive Control: 293T, Raji or hPBL Cells. Tonsil or Spleen.
• Cellular Localization: Cytoplasm, Cell Surface and Secreted
• Chromosome Location: 14q32.33
• Preparation and Storage: Antibody with azide - store at 2 to 8 degree C.; Antibody without azide - store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified IgM Rabbit Recombinant Monoclonal Antibody (IGHM/2559R). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Tonsil stained with IgM Rabbit Recombinant Monoclonal Antibody (IGHM/2559R).)

Related Product Information for anti-IgM antibody

Recombinant Rabbit Monoclonal Antibody

References

Baryshnikov AIu. Gematol Transfuziol. 1990 Aug; 35(8):4-7.

NCBI and Uniprot Product Information

• NCBI GI #: 1160421986
• NCBI GeneID: 3507
• UniProt Accession #: P01871; P04220; P20769; A0A075B6N9; A0A0G2JQL4
• Molecular Weight: 50-75kDa
• NCBI Official Full Name: Immunoglobulin heavy constant mu
• NCBI Official Synonym Full Names: immunoglobulin heavy constant mu
• NCBI Official Symbol: IGHM
• NCBI Official Synonym Symbols: MU; VH; AGM1
• UniProt Protein Name: Immunoglobulin heavy constant mu
• UniProt Gene Name: IGHM