IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with INSM-1 Recombinant Rabbit Monoclonal Antibody (INSM1/6286R).)
Rabbit anti-Human INSM1 Monoclonal Antibody | anti-INSM1 antibody
INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody [Clone INSM1/6286R]
Gene Names
INSM1; IA1; IA-1
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
INSM1, Antibody; INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody [Clone INSM1/6286R]; INSM1 (Pan-Neuroendocrine Marker); IA1; Insulinoma associated protein 1 (IA1); Zinc finger protein IA1; anti-INSM1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit/IgG
Clone Number
INSM1/6286R
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)
Applicable Applications for anti-INSM1 antibody
IHC (Immunohistochemistry)
Antibody Type
Recombinant Antibody
Immunogen
Recombinant fragment (around aa81-125) corresponding to the N-terminus of human INSM1
Cellular Localization
Nuclear
Positive Control
Human pancreas or neuroendocrine tumor.
Hu-chromosome Location
20p11.23
Unigene
89584
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with INSM-1 Recombinant Rabbit Monoclonal Antibody (INSM1/6286R).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human neuroendocrine tumor stained with INSM-1 Recombinant Rabbit Monoclonal Antibody (INSM1/6286R).)
Related Product Information for anti-INSM1 antibody
Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95% of lung small cell carcinoma and 91% of lung large cell neuroendocrine carcinoma, compared with 75% and 78% with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56). INSM1 stains 100% of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3% of adenocarcinomas and 4% of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
52,923 Da
NCBI Official Full Name
insulinoma-associated protein 1
NCBI Official Synonym Full Names
insulinoma-associated 1
NCBI Official Symbol
INSM1
NCBI Official Synonym Symbols
IA1; IA-1
NCBI Protein Information
insulinoma-associated protein 1; zinc finger protein IA-1
UniProt Protein Name
Insulinoma-associated protein 1
UniProt Gene Name
INSM1
UniProt Synonym Gene Names
IA1
UniProt Entry Name
INSM1_HUMAN
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Product Notes
The INSM1 insm1 (Catalog #AAA215749) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INSM1 (Pan-Neuroendocrine Marker) Recombinant Rabbit Monoclonal Antibody [Clone INSM1/6286R] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's INSM1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the INSM1 insm1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "INSM1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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