IHC (Immunohiostchemistry)
(INSM1 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Carcinoma Tissue)
Rabbit anti-Human INSM1 Monoclonal Antibody | anti-INSM1 antibody
INSM1 (RBT-INSM1)
Reactivity
Human
Synonyms
INSM1, Antibody; INSM1 (RBT-INSM1); insm-1; anti-insm1; anti insm1; IA 1; IA1; insulinoma associated 1; insulinoma associated protein 1; INSM1; Zinc finger protein IA 1; anti-INSM1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG
Clone Number
RBT-INSM1
Form/Format
Paraffin, Frozen
INSM1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
INSM1 is a rabbit monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH7.5, containing BSA and sodium azide as a preservative.
Immunogen
Synthetic peptide corresponding to residues from the N-terminal domain of the human INSM1 protein.
Control
Pancreas, Colon, Tonsil, Neuroendocrine Lung Cancer, Endometrial Carcinoma, Colon Carcinoma
Localization
Nuclear
Preparation and Storage
Store at 2-8 degree C (Control Slides: Store at 20-25 degree C)
IHC (Immunohiostchemistry)
(INSM1 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Carcinoma Tissue)
IHC (Immunohiostchemistry)
(INSM1 Antibody Immunohistochemistry on an FFPE Lung Neuroendocrine Carcinoma Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-INSM1 antibody
Insulinoma-associated 1 (INSM1) gene encodes a protein containing both a zinc finger DNA-binding domain and a putative prohormone domain, originally isolated from a human insulinoma-glucagonoma subtraction library.
INSM1 antibody is abundantly expressed in fetal neuroendocrine developmental tissues and expressed in normal adult neuroendocrine (NE) tissues (adrenal medulla, pineal gland, pituitary gland, gastrointestinal enterochromaffin cells, pancreatic islet cells, thyroid C cells) and developing neurons. However there is also a high occurrence of INSM1 found in NE tumors, such as small cell lung cancer (SCLC), pituitary tumors, medullary thyroid carcinoma, Merkel cell carcinoma, olfactory neuroblastoma and pheochromocytoma. It has been reported that INSM1 expresses exclusively in SCLC specimens using immunohistochemistry, and first elucidated that INSM1 regulates the NE differentiation pathway in lung cancer. In addition, it has demonstrated an increased sensitivity and specificity compared to other NE biomarkers (Chromogranin A, Synaptophysin and CD56) in lung cancer specimens. In addition, it's been shown to be involved in NE differentiation in medullary thyroid carcinoma, pheochromocytoma, intestinal NE carcinoma, islet cell tumor, pituitary tumor, and SCLC cell lines.
INSM1 antibody is abundantly expressed in fetal neuroendocrine developmental tissues and expressed in normal adult neuroendocrine (NE) tissues (adrenal medulla, pineal gland, pituitary gland, gastrointestinal enterochromaffin cells, pancreatic islet cells, thyroid C cells) and developing neurons. However there is also a high occurrence of INSM1 found in NE tumors, such as small cell lung cancer (SCLC), pituitary tumors, medullary thyroid carcinoma, Merkel cell carcinoma, olfactory neuroblastoma and pheochromocytoma. It has been reported that INSM1 expresses exclusively in SCLC specimens using immunohistochemistry, and first elucidated that INSM1 regulates the NE differentiation pathway in lung cancer. In addition, it has demonstrated an increased sensitivity and specificity compared to other NE biomarkers (Chromogranin A, Synaptophysin and CD56) in lung cancer specimens. In addition, it's been shown to be involved in NE differentiation in medullary thyroid carcinoma, pheochromocytoma, intestinal NE carcinoma, islet cell tumor, pituitary tumor, and SCLC cell lines.
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Product Notes
The INSM1 (Catalog #AAA59417) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The INSM1 (RBT-INSM1) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "INSM1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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