Mouse anti-Human Kallikrein 5 (KLK5) Monoclonal Antibody | anti-KLK5 antibody

Kallikrein 5 (KLK5)

Cat. Num. AAA215354

• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: Kallikrein 5 (KLK5), Antibody; Kallikrein 5 (KLK5); HK5; Kallikrein L2; Kallikrein like protein 2; Kallikrein related peptidase 5; Kallikrein-like protein 2 (KLKL2); Stratum corneum tryptic enzyme (SCTE); anti-KLK5 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2c, kappa
• Clone Number: KLK5/3841
• Specificity: Kallikreins (KLKs) belong to the serine protease family of proteolytic enzymes. Human pancreatic/renal KLK encodes for the KLK1 enzyme, which is involved in post-translational processing of polypeptide precursors. The function of the other members of KLK gene family is still currently unknown, but evidence suggests that many KLKs are implicated in carcinogenesis. The human KLK gene family consists of 15 serine proteases. The human KLK genes are clustered on chromosome 19q13. Unlike other kalllikreins, the KLK4-15 encoded proteases are less related and do not contain a conventional KLK loop. Clusters of genes exhibit high prostatic (KLK2-4, KLK15) or pancreatic (KLK6-13) expression. KLK2 is also known as glandular kallikrein 2, tissue kallikrein, or HGK-1 and KLK3 is known as prostate-specific antigen (PSA). Both KLK2 and KLK3 have important applications in prostate cancer and breast cancer identification. Many of the KLKs are regulated by steroid hormones and a few of them, specifically KLK3, KLK6 and KLK10, are known to be downregulated in breast and other cancers. KLK5 expression is abundant in skin, mammary gland and testis.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 293

• Applicable Applications for anti-KLK5 antibody: IHC (Immunohistochemistry)
• Immunogen: Recombinant fragment of Human KLK5 protein (around aa 36-177) (exact sequence is proprietary)
• Cellular Localization: Secreted
• Hu-chromosome Location: 19q13.33
• Positive Control: Human skin tissue (IHC).
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Application Data

(Analysis of Protein Array containing more than 19,000 full-length human proteins using Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841) Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)

IHC (Immunohistochemisry)

(Formalin-fixed, paraffin-embedded human skin stained with Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841).)

SDS-PAGE

(SDS-PAGE Analysis Purified Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841). Confirmation of Integrity and Purity of Antibody)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human skin stained with Kallikrein 5 Mouse Monoclonal Antibody (KLK5/3841).)

References

Diamandis, E.P., et al. 2000. The new human kallikrein gene family: implications in carcinogenesis. Trends Endocrinol. Metab. 11: 54-60.

NCBI and Uniprot Product Information

• NCBI GI #: 296434569
• UniProt Accession #: Q9Y337
• Molecular Weight: 33kDa
• NCBI Official Full Name: Kallikrein-5
• UniProt Protein Name: Kallikrein-5
• UniProt Gene Name: KLK5
• UniProt Synonym Gene Names: SCTE; KLK-L2
• UniProt Entry Name: KLK5_HUMAN