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Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using CDH16-Monospecific Mouse Monoclonal Antibody (CDH16/2125). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse anti-Human Ksp-Cadherin/CDH16 Monoclonal Antibody | anti-CDH16 antibody
Ksp-Cadherin/CDH16 (Renal Cell Marker)
Reactivity
Human
Applications
Western Blot, Immunohistochemistry, ELISA
Purity
Purified Ab conjugated to Biotin
Synonyms
Ksp-Cadherin/CDH16, Antibody; Ksp-Cadherin/CDH16 (Renal Cell Marker); Cadherin-16 (CDH16); Kidney-specific cadherin; Ksp-cadherin antibody; anti-CDH16 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
CDH16/2125
Specificity
This MAb recognizes a protein of 130kDa, identified as Ksp-cadherin. Cadherins form a superfamily of related glycoproteins that mediate calcium-dependent cell adhesion and transmit signals from the extracellular matrix to the cytoplasm. Cadherins have been implicated in embryogenesis, tissue morphogenesis, tissue structure maintenance, cell polarization, neoplastic invasiveness and metastasis, and membrane transport.It is suggested that Ksp-cadherin is a marker for terminal differentiation of the basolateral membranes of renal tubular epithelial cells.Within the kidney, Ksp-Cadherin is found exclusively in the basolateral membrane of renal tubular epithelial cells and collecting duct cells, and not in glomeruli, renal interstitial cells, or blood vessels.Ksp-Cadherin has been suggested to distinguish Chromophobe Renal-Cell Carcinoma from Oncocytoma.
Purity/Purification
Purified Ab conjugated to Biotin
Form/Format
Antibody purified from Bioreactor Concentrate by Protein A/G and conjugated to Biotin. Prepared in 10mM PBS with 0.05% BSA and 0.05% azide.
Sequence Length
807
Applicable Applications for anti-CDH16 antibody
WB (Western Blot), IHC (Immunohistochemistry), ELISA
Immunogen
Recombinant fragment (around aa 371-507) of Human CDH16 protein (exact sequence is proprietary)
Cellular Localization
Cell Surfaceand Cytoplasmic
Hu-chromosome Location
16q22.1
Positive Control
Normal kidney or Renal cell carcinoma.
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using CDH16-Monospecific Mouse Monoclonal Antibody (CDH16/2125). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using CDH16-Monospecific Mouse Monoclonal Antibody (CDH16/2125). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
SDS-PAGE
(SDS-PAGE Analysis Purified CDH16 Mouse Monoclonal Antibody (CDH16/2125) (unconjugated). Confirmation of Integrity and Purity of Antibody.)
SDS-PAGE
(SDS-PAGE Analysis Purified CDH16 Mouse Monoclonal Antibody (CDH16/2125) (unconjugated). Confirmation of Integrity and Purity of Antibody.)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with Biotin-conjugated CDH16Mouse Monoclonal Antibody (CDH16/2125).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with Biotin-conjugated CDH16Mouse Monoclonal Antibody (CDH16/2125).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with Biotin-conjugated CDH16Mouse Monoclonal Antibody (CDH16/2125).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human kidney stained with Biotin-conjugated CDH16Mouse Monoclonal Antibody (CDH16/2125).)
References
Shen, S.S., et al. 2005. Mod Pathol. 18: 933-40. | Mazal, P.R., et al. 2005. Hum Pathol. 36: 22-28.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
130kDa
NCBI Official Full Name
cadherin-16 isoform 2
NCBI Official Synonym Full Names
cadherin 16
NCBI Official Symbol
CDH16
NCBI Protein Information
cadherin-16
UniProt Protein Name
Cadherin-16
UniProt Gene Name
CDH16
UniProt Synonym Gene Names
Ksp-cadherin
UniProt Entry Name
CAD16_HUMAN
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Product Notes
The CDH16 cdh16 (Catalog #AAA215475) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Ksp-Cadherin/CDH16 (Renal Cell Marker) reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Ksp-Cadherin/CDH16 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), ELISA. Researchers should empirically determine the suitability of the CDH16 cdh16 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ksp-Cadherin/CDH16, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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