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IHC (Immunohistochemistry)
(Figure 4. Immunohistochemistry on frozen tissue section of human skin showing nuclear lamina staining in epithelial and connective tissue cells.)
Mouse Lamin A and C Monoclonal Antibody | anti-lmna antibody
Mouse anti Lamin A and C
Gene Names
lmna; lmna-A
Reactivity
Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
Applications
Western Blot, Immunohistochemistry, Immunocytochemistry, Flow Cytometry, Functional Assay
Synonyms
Lamin A and C, Antibody; Mouse anti Lamin A and C; anti-lmna antibody
Host
Mouse
Reactivity
Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep
Clonality
Monoclonal
Isotype
IgG1
Clone Number
131C3
Specificity
131C3 reacts with an epitope loCated between residues 319-566 in lamin A and C.
Form/Format
Each vial contains 100 ul 1 mg/ml purified monoclonal antibody in PBS containing 0.09% sodium azide.
Applicable Applications for anti-lmna antibody
WB (Western Blot), IHC (Immunohistochemistry), ICC (Immunocytochemistry), FCM/FACS (Flow Cytometry)
Source Note
131C3 is a Mouse monoclonal IgG1/k antibody derived by fusion of P3/X63.Ag8.653 Mouse myeloma cells with spleen cells from a BALB/c Mouse immunized with purified Rat liver lamins.
Preparation and Storage
Store at 4 degree C, or in small aliquots at -20 degree C.
IHC (Immunohistochemistry)
(Figure 4. Immunohistochemistry on frozen tissue section of human skin showing nuclear lamina staining in epithelial and connective tissue cells.)
IHC (Immunohistochemistry)
(Figure 4. Immunohistochemistry on frozen tissue section of human skin showing nuclear lamina staining in epithelial and connective tissue cells.)
IB (Immunoblot)
(Figure 3. Immunoblotting result (131C3) recognizing nuclear lamins A and C in human fibroblasts.)
IB (Immunoblot)
(Figure 3. Immunoblotting result (131C3) recognizing nuclear lamins A and C in human fibroblasts.)
IHC (Immunohiostchemistry)
(Figure 2. Immunohistochemistry (131C3) on frozen sections of human colon showing strong positive staining in nuclei of the epithelial cells and to a lesser extent in the connective tissue.)
IHC (Immunohiostchemistry)
(Figure 2. Immunohistochemistry (131C3) on frozen sections of human colon showing strong positive staining in nuclei of the epithelial cells and to a lesser extent in the connective tissue.)
IHC (Immunohistochemistry)
(Figure 1. Immunohistochemistry on frozen sections of swine skin showing strong positive staining in nuclei of the epidermal cells and to a lesser extent in the connective tissue. Dilution 1:500.)
IHC (Immunohistochemistry)
(Figure 1. Immunohistochemistry on frozen sections of swine skin showing strong positive staining in nuclei of the epidermal cells and to a lesser extent in the connective tissue. Dilution 1:500.)
Related Product Information for anti-lmna antibody
Nuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
Product Categories/Family for anti-lmna antibody
References
Pugh, G. E., Coates, P. J., Lane, E. B., Raymond, Y., and Quinlan, R. A. (1997). Distinct nuclear assembly pathways for lamins A and C lead to their increase during quiescence in Swiss 3T3 cells, J Cell Sci 110, 2483-93. Neri, L. M., Raymond, Y., Giordano, A., Borgatti, P., Marchisio, M., Capitani, S., and Martelli, A. M. (1999). Spatial distribution of lamin A and B1 in the K562 cell nuclear matrix stabilized with metal ions, J Cell Biochem 75, 36-45. Neri, L. M., Raymond, Y., Giordano, A., Capitani, S., and Martelli, A. M. (1999). Lamin A is part of the internal nucleoskeleton of Human erythroleukemia cells, J Cell Physiol 178, 284-95.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
74,919 Da
NCBI Official Full Name
lamin-A
NCBI Official Synonym Full Names
lamin A/C<
NCBI Official Symbol
lmna
NCBI Official Synonym Symbols
lmna-A
NCBI Protein Information
lamin-A
UniProt Protein Name
Lamin-A
UniProt Gene Name
lmna
UniProt Entry Name
LMNA_XENLA
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Product Notes
The lmna lmna (Catalog #AAA77495) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Mouse anti Lamin An and C reacts with Bovine, Canine, Hamster, Human, Mouse, Rat, Sheep and may cross-react with other species as described in the data sheet. AAA Biotech's Lamin An and C can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), IHC (Immunohistochemistry), ICC (Immunocytochemistry), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the lmna lmna for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Lamin A and C, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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