Mouse anti-Human LAMP-2 Monoclonal Antibody | anti-LAMP-2 antibody
LAMP-2, Human, mAb C8
Reactivity
Human
Applications
Flow Cytometry, Functional Assay
Synonyms
LAMP-2, Antibody; LAMP-2, Human, mAb C8; LAMP-2, Human, clone C8; Lysosome-associated membrane glycoprotein 2; Lysosome-associated membrane protein 2; CD107 antigen-like family member B; LGP-96; anti-LAMP-2 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
Mouse IgG2b
Clone Number
C8
Form/Format
0.2 ml (100 ug/ml) 0.2 um filtered protein G purified antibody solution in PBS, containing 0.1% bovine serum albumin and 0.02 % sodium azide.
Applicable Applications for anti-LAMP-2 antibody
IA (Immunoassay), FCM/FACS (Flow Cytometry)
Immunogen
Lamp-2 protein
Preparation and Storage
Product should be stored at 4 degree C. Under recommended storage conditions, product is stable for at least one year.
Related Product Information for anti-LAMP-2 antibody
Monoclonal antibody HM2372, clone C8 recognizes human lysosome-associated membrane protein-2 (LAMP-2; CD107b). LAMP-2 is a heavily glycosylated membrane protein expressed in lysosomes of 383 amino acids. It is a member of a family of membrane glycoproteins like MAP-1, LIMP2 and DC-LAMP. LAMP-2 is expressed in a broad panel of tissues like placenta, lung, liver and kidney. Glycosylation is dependent on cell type and activation status. LAMP-2 exists in three splice variants LAMP-2A, LAMP-2B and LAMP-2C. They differ in their sequence in the transmembrane and cytoplasmic domain that effects their function. LAMP-2 is important for control of lysosomal activity and traffic across the lysosomal membranes. Its ability to mediate fusion between auto phagosomes and lysosomes makes it important for the process of autophagy. The protein is also involved in cholesterol transport and cytoplasmic antigen MHCII presentation. Normally LAMP-2 is expressed at low levels on the cell surface. The degree of surface expression is dependent on the cell type and state of activation. Genetic deficiency of LAMP-2 causes Danon disease inducing cardiomyopathy and myopathy. Recent studies show also involvement in ANCA-vasculitis.
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Product Notes
The LAMP-2 (Catalog #AAA77819) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The LAMP-2, Human, mAb C8 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's LAMP-2 can be used in a range of immunoassay formats including, but not limited to, IA (Immunoassay), FCM/FACS (Flow Cytometry). Researchers should empirically determine the suitability of the LAMP-2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "LAMP-2, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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