Bioactivity
(Detects CD33 in indirect ELISAs.)
anti-Human Lintuzumab Monoclonal Antibody | anti-CD33 antibody
Research Grade Lintuzumab
Gene Names
CD33; p67; SIGLEC3; SIGLEC-3
Reactivity
Human
Purity
>95% by SDS-PAGE. Protein A or G purified from cell culture supernatant.
Synonyms
Lintuzumab, Antibody; Research Grade Lintuzumab; 225Ac-lintuzumab; HuM195; SGN-33; SMART M195; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; CD33; gp67; SIGLEC3; anti-CD33 antibody
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1-kappa
Purity/Purification
>95% by SDS-PAGE. Protein A or G purified from cell culture supernatant.
Form/Format
Liquid. 0.01M PBS, pH7.4
Concentration
1.39 mg/ml (varies by lot)
Expression System
XtenCHO
Host Species
Humanized
CAS
166089-32-3
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.
Preparation and Storage
Store at +4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
Bioactivity
(Detects CD33 in indirect ELISAs.)
Bioactivity
(Detects CD33 in indirect ELISAs.)
SDS-PAGE
(SDS PAGE for Lintuzumab)
SDS-PAGE
(SDS PAGE for Lintuzumab)
Related Product Information for anti-CD33 antibody
Lintuzumab is a humanized monoclonal antibody, HuM195, that targets the cell surface antigen CD33 that is expressed on the vast majority of acute myeloid leukemia (AML) cells. [225 Ac]Ac-lintuzumab clinical trials were discussed in detail in reference. Lintuzumab is under investigation in clinical trial NCT00016159 (Chemotherapy Plus Monoclonal Antibody in Treating Patients With Acute Promyelocytic Leukemia).
Product Categories/Family for anti-CD33 antibody
References
Investigational CD33-targeted therapeutics for acute myeloid leukemia, PMID: 29534618
CD33-Targeted Therapies: Beating the Disease or Beaten to Death?, PMID: 32875599
Targeted Alpha-Particle Therapy for Hematologic Malignancies, PMID: 31253514
Targeted Alpha-Particle Therapy for Hematologic Malignancies, PMID: 32172800
Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia, PMID: 20065652
CD33-Targeted Therapies: Beating the Disease or Beaten to Death?, PMID: 32875599
Targeted Alpha-Particle Therapy for Hematologic Malignancies, PMID: 31253514
Targeted Alpha-Particle Therapy for Hematologic Malignancies, PMID: 32172800
Anti-leukemic activity of lintuzumab (SGN-33) in preclinical models of acute myeloid leukemia, PMID: 20065652
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Official Full Name
Myeloid cell surface antigen CD33
NCBI Official Synonym Full Names
CD33 molecule
NCBI Official Symbol
CD33
NCBI Official Synonym Symbols
p67; SIGLEC3; SIGLEC-3
NCBI Protein Information
myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3
UniProt Protein Name
Myeloid cell surface antigen CD33
UniProt Gene Name
CD33
UniProt Synonym Gene Names
SIGLEC3; Siglec-3
UniProt Entry Name
CD33_HUMAN
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Product Notes
The CD33 cd33 (Catalog #AAA120059) is an Antibody and is intended for research purposes only. The product is available for immediate purchase. The Research Grade Lintuzumab reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Lintuzumab, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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