Mouse anti-Human MDMX Monoclonal Antibody | anti-MDMX antibody

MDMX Monoclonal Antibody

Cat. Num. AAA320152

• Gene Names: MDM4; HDMX; MDMX; MRP1
• Reactivity: Human
• Applications: ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Western Blot
• Purity: Affinity purification
• Synonyms: MDMX, Antibody; MDMX Monoclonal Antibody; Protein Mdm4; MDM4; MDMX; Double minute 4 protein; Mdm2-like p53-binding protein; Protein Mdmx; p53-binding protein Mdm4; anti-MDMX antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Specificity: MDMX Monoclonal Antibody detects endogenous levels of MDMX protein.
• Purity/Purification: Affinity purification
• Form/Format: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

• Applicable Applications for anti-MDMX antibody: ELISA, ICC (Immunocytochemistry), IF (Immunofluorescence), IHC (Immunohistochemistry), WB (Western Blot)
• Immunogen: Purified recombinant fragment of human MDMX expressed in E coli.
• Modification: Unmodified/Total
• Preparation and Storage: Store at -20 degree C/1 year

IF (Immunofluorescence)

(Confocal immunofluorescence analysis of Hela (left) and L-02 (right) cells using MDMX Monoclonal Antibody (green). Red: Actin filaments have been labeled with DY-554 phalloidin.)

IHC (Immunohiostchemistry)

(Immunohistochemistry analysis of paraffin-embedded human cerebra (left) and lung carcinoma (right) tissues. showing nuclear localization with DAB staining using MDMX Monoclonal Antibody.)

WB (Western Blot)

(Western Blot analysis using MDMX Monoclonal Antibody against HeLa (1). A549 (2) and A431 (3) cell lysate.)

Related Product Information for anti-MDMX antibody

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

Product Categories/Family for anti-MDMX antibody

Primary Antibodies

NCBI and Uniprot Product Information

• NCBI GI #: 323510634
• NCBI GeneID: 4194
• NCBI Accession #: NP_001191100.1
• NCBI GenBank Nucleotide #: NM_001204171.1
• UniProt Accession #: O15151; Q2M2Y2; Q32SL2; Q6GS18; Q8IV83
• Molecular Weight: 54,864 Da
• NCBI Official Full Name: protein Mdm4 isoform 2
• NCBI Official Synonym Full Names: Mdm4 p53 binding protein homolog (mouse)
• NCBI Official Symbol: MDM4
• NCBI Official Synonym Symbols: HDMX; MDMX; MRP1
• NCBI Protein Information: protein Mdm4; protein Mdmx; MDM4-related protein 1; mdm2-like p53-binding protein; double minute 4, human homolog of; p53-binding protein
• UniProt Protein Name: Protein Mdm4
• UniProt Gene Name: MDM4
• UniProt Synonym Gene Names: MDMX
• UniProt Entry Name: MDM4_HUMAN