Mouse anti-Human MMP9 (Matrix Metalloproteinase 9) Monoclonal Antibody | anti-MMP9 antibody

MMP9 (Matrix Metalloproteinase 9)

Cat. Num. AAA215090

• Gene Names: MMP9; GELB; CLG4B; MMP-9; MANDP2
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: MMP9 (Matrix Metalloproteinase 9), Antibody; MMP9 (Matrix Metalloproteinase 9); 82 kDa matrix metalloproteinase-9; 92 kDa type IV collagenase; CLG 4B; CLG4B; Collagenase Type 4 beta; Collagenase type IV 92 KD; EC 3.4.24.35; Gelatinase 92 KD; Gelatinase B; Gelatinase beta; GELB; Macrophage gelatinase; MANDP2;; anti-MMP9 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: 2C3
• Specificity: The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is down-regulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified by Protein A. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 707

• Applicable Applications for anti-MMP9 antibody: IHC (Immunohistochemistry)
• Positive Control: Human spleen tissue or human heart tissue. U937 cells. Human PBL whole cell lysate.
• Immunogen: A synthetic peptide corresponding to amino acids 603-614 of human MMP-9
• Cellular Localization: Cytoplasm, extracellular matrix.
• Hu-chromosome Location: 20q13.12
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis of Purified MMP9 Mouse Monoclonal Antibody (2C3). Confirmation of Integrity and Purity of Antibody)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Spleen stained with MMP9 Mouse Monoclonal Antibody (2C3).)

References

1. Thanakit V, Sampatanukul P, Ruangvejvorachai P, Keelawat S. J Med Assoc Thai. 2005 Sep;88 Suppl 4:S30-5. 2. Elsasser, A., et al. 2004. J. Am. Coll. Cardiol. 43: 2191-2199

NCBI and Uniprot Product Information

• NCBI GI #: 74272287
• NCBI GeneID: 4318
• NCBI Accession #: NP_004985.2
• NCBI GenBank Nucleotide #: NP_004985.2
• UniProt Accession #: P14780
• Molecular Weight: 92kDa
• NCBI Official Full Name: matrix metalloproteinase-9 preproprotein
• NCBI Official Synonym Full Names: matrix metallopeptidase 9
• NCBI Official Symbol: MMP9
• NCBI Official Synonym Symbols: GELB; CLG4B; MMP-9; MANDP2
• NCBI Protein Information: matrix metalloproteinase-9
• UniProt Protein Name: Matrix metalloproteinase-9
• UniProt Gene Name: MMP9
• UniProt Synonym Gene Names: CLG4B; MMP-9; GELB
• UniProt Entry Name: MMP9_HUMAN