Mouse anti-Human MUC16/CA125 Monoclonal Antibody | anti-CA125 antibody

MUC16/CA125 (Ovarian Carcinoma Marker)

Cat. Num. AAA215358

• Gene Names: MUC16; CA125
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: MUC16/CA125, Antibody; MUC16/CA125 (Ovarian Carcinoma Marker); CA125; Cancer antigen 125; MUC16; Mucin16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125; anti-CA125 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG1, kappa
• Clone Number: OCA125/1900
• Specificity: The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml or Purified Ab with BSA and Azide at 200ug/ml or Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 14507

• Applicable Applications for anti-CA125 antibody: IHC (Immunohistochemistry)
• Immunogen: Full length native MUC16 proteinPurified fromHuman ovarian carcinoma
• Cellular Localization: Cell Surfaceand Secreted
• Hu-chromosome Location: 19p13.2
• Positive Control: MDA-MB-468 cells. Ovarian Cancer
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified MUC16 Mouse Monoclonal Antibody (OCA125/1900). Confirmation of Integrity and Purity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Ovarian Carcinoma stained with MUC16 Mouse Monoclonal Antibody (OCA125/1900).)

References

Yin, B.W., et al. 2001. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J. Biol. Chem. 276:27371-27375.

NCBI and Uniprot Product Information

• NCBI GI #: 83367077
• NCBI GeneID: 94025
• NCBI Accession #: NP_078966.2
• NCBI GenBank Nucleotide #: NP_078966.2
• UniProt Accession #: Q8WXI7
• Molecular Weight: >2;000kDa
• NCBI Official Full Name: mucin-16
• NCBI Official Synonym Full Names: mucin 16, cell surface associated
• NCBI Official Symbol: MUC16
• NCBI Official Synonym Symbols: CA125
• NCBI Protein Information: mucin-16
• UniProt Protein Name: Mucin-16
• UniProt Gene Name: MUC16
• UniProt Synonym Gene Names: CA125; MUC-16; CA-125
• UniProt Entry Name: MUC16_HUMAN