Mouse Nav1.7 Monoclonal Antibody | anti-SCN9A antibody

Nav1.7 Antibody

Cat. Num. AAA103382

• Gene Names: SCN9A; PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; Nav1.7
• Reactivity: Human, Mouse, Rat, Hamster
• Applications: Immunofluorescence, Immunocytochemistry, Immunohistochemistry, Immunoprecipitation, Western Blot
• Purity: Protein G Purified
• Synonyms: Nav1.7, Antibody; Nav1.7 Antibody; ETHA; hNE Na; NE NA; PN1; SCN9A; voltage gated sodium channel subunit alpha Nav1; peripheral sodium channel 1; neuroendocrine sodium channel; anti-SCN9A antibody

• Host: Mouse
• Reactivity: Human, Mouse, Rat, Hamster
• Clonality: Monoclonal
• Isotype: IgG1
• Clone Number: N68/6 (formerly sold as S68-6)
• Specificity: Detects ~230kDa. No cross-reactivity against other Nav channels.
• Purity/Purification: Protein G Purified
• Form/Format: PBS pH7.4, 50% glycerol, 0.09% sodium azide
• Concentration: 1mg/ml (varies by lot)
• Sequence Length: 1977

• Applicable Applications for anti-SCN9A antibody: AM (Antibody Microarray), IF (Immunofluorescence), ICC (Immunocytochemistry), IHC (Immunohistochemistry), IP (Immunoprecipitation), WB (Western Blot)
• Certificate of Analysis: 1 ug/mL of MBS804140 was sufficient for detection of Nav1.7 in 10ug of HEK-293 cell lysate transiently expressing Nav1.7 by colorimetric immunoblot analysis using Goat anti-mouse IgG: HRP as the secondary antibody.
• Immunogen: Fusion protein amino acids 1751-1946 (C-terminus) of human Nav1.7
• Research Area: Neuroscience| Ion Channels| Sodium Channels| Voltage-Gated Sodium Channels| Cancer| Cell Signaling
• Cellular Localization: Membrane| Synapse
• Preparation and Storage: Ships on blue ice. Store -20 degree C. Avoid freeze/thaw cycle.

Related Product Information for anti-SCN9A antibody

Nav1.7 is a voltage-gated sodium channel and plays a critical role In the generation and conduction of action potentials and is thus important for electrical signaling by most excitable cells. Therapeutically, the association of pain insensitivity with the loss offunction of a certain sodium channel may have implications. Since Nav1.7 is not present in cardiac muscle or neurons in the central nervous system,blockers of Nav1.7will not have direct action on these cells and thus can have less side effects than current pain medications. By performing more studies,there is a possibility to develop a new generation of drugs that can reduce the pain intensity in animals (1-3).

Product Categories/Family for anti-SCN9A antibody

Ion Channels; Neuroscience

References

1. Hille B. (2001) Ion Channels of Excitable Membranes, 3rd Ed., Sinauer Associated Inc.: Sunderland, MA USA. 2. www.iochannels.org 3. Dray A. (2008) Br. J. Anaesth. 101(1): 48-58. 4. Dray A., Read S.J (2007) Arthritis Res. Ther. 9(3): 212. 5. Samuels M.E., teMorshe R.H., Lynch M.E., Drenth J.P. (2008) Mol Pain. 4: 21.

NCBI and Uniprot Product Information

• NCBI GI #: 4506813
• NCBI GeneID: 6335
• NCBI Accession #: NP_002968.1
• NCBI GenBank Nucleotide #: NM_002977.3
• UniProt Accession #: Q15858; Q6B4R9; Q6B4S0; Q6B4S1; Q70HX1; Q70HX2; Q8WTU1; Q8WWN4; A1BUH5
• NCBI Official Full Name: sodium channel protein type 9 subunit alpha
• NCBI Official Synonym Full Names: sodium channel, voltage-gated, type IX, alpha subunit
• NCBI Official Symbol: SCN9A
• NCBI Official Synonym Symbols: PN1; ETHA; NENA; SFNP; FEB3B; NE-NA; GEFSP7; Nav1.7
• NCBI Protein Information: sodium channel protein type 9 subunit alpha; hNE-Na; peripheral sodium channel 1; neuroendocrine sodium channel; sodium channel protein type IX subunit alpha; voltage-gated sodium channel alpha subunit Nav1.7; voltage-gated sodium channel subunit alpha Nav1.7; sodium channel, voltage-gated, type IX, alpha polypeptide
• UniProt Protein Name: Sodium channel protein type 9 subunit alpha
• UniProt Gene Name: SCN9A
• UniProt Synonym Gene Names: NENA; hNE-Na; PN1
• UniProt Entry Name: SCN9A_HUMAN