Mouse Neutrophil gelatinase-associated lipocalin/NGAL Monoclonal Antibody | anti-NGAL antibody

Mouse anti-human Neutrophil gelatinase-associated lipocalin/NGAL monoclonal antibody

Cat. Num. AAA230792

• Gene Names: LCN2; p25; 24p3; MSFI; NGAL
• Applications: ELISA
• Purity: >95% by Protein G purified
• Synonyms: Neutrophil gelatinase-associated lipocalin/NGAL, Antibody; Mouse anti-human Neutrophil gelatinase-associated lipocalin/NGAL monoclonal antibody; 25 kDa alpha-2-microglobulin-related subunit of MMP-9; Lipocalin-2; Oncogene 24p3; p25; LCN2; HNL; NGAL; anti-NGAL antibody

• Host: Mouse
• Clonality: Monoclonal
• Isotype: IgG2b
• Purity/Purification: >95% by Protein G purified
• Form/Format: Liquid
• Sequence Length: 198

• Applicable Applications for anti-NGAL antibody: CLIA (Chemiluminescence Immunoassay), ICT (Immunochromatography), ELISA
• Product Note: Applications are user defined. Product is developed and quality control tested in house, data or additional information may be provided upon request. The researcher needs to establish and confirm the suitability of the product for their application.
• Preparation and Storage: Shipped at 4 degree C Upon delivery aliquot and store at -20 degree C or -80 degree C. Avoid repeated freeze.

Related Product Information for anti-NGAL antibody

Background/Introduction: Irisin is the soluble cleavage product of Fibronectin type III domain-containing protein 5 (FNDC5) and is named after Iris, the messenger of the Gods found in Greek mythology. The FNDC5 gene encodes a single-pass type I membrane pro-hormone (human, 212 amino acids; mouse and rat, 209 amino acids). Irisin is synthesized like the production of other hormones and hormone-like polypeptides such as epidermal growth factor and TGF alpha. After the N-terminal signal peptide of FNDC5 is excised, Irisin is proteolytically cleaved from the C-terminal moiety, glycosylated, and released as a hormone of 112 amino acids (in human, amino acids 32-143 of the full-length protein; in mouse and rat, amino acids 29-140) that contains much of the FNIII repeat region (Figure 1). In mice, exercise causes increased muscle expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1alpha), which is involved in adaptive responses to exercise. Upregulation of PGC-1alpha causes expression of FNDC5 which is processed to Irisin. Since Irisin is produced through a mechanism started by muscle activity, Irisin is considered to be a myokine. Demonstration that FNDC5 causes an increase in thermogenin expression in fat cells, that overexpression of FNDC5 in mouse liver blocks diet-induced weight gain, and FNDC5 levels of mRNA are increased in human muscle post-exercise, have led researchers to propose that Irisin stimulates white fat to brown fat conversion which would suggest it is a health promoting hormone in humans. Irisin ELISA Kit is an enzyme immunoassay developed for the detection and quantitation of Irisin in plasma, serum, urine, cell or tissue lysate samples. The kit has a detection sensitivity limit of 6.25 ng/mL Irisin. Each kit provides sufficient reagents to perform up to 96 assays including standard curve and unknown samples.

Product Categories/Family for anti-NGAL antibody

Renal Function & Injury; Raw Materials Assay Development

NCBI and Uniprot Product Information

• NCBI GI #: 38455402
• NCBI GeneID: 3934
• NCBI Accession #: NP_005555.2
• NCBI GenBank Nucleotide #: NM_005564.4
• NCBI Official Full Name: neutrophil gelatinase-associated lipocalin
• NCBI Official Synonym Full Names: lipocalin 2
• NCBI Official Symbol: LCN2
• NCBI Official Synonym Symbols: p25; 24p3; MSFI; NGAL
• NCBI Protein Information: neutrophil gelatinase-associated lipocalin
• UniProt Protein Name: Neutrophil gelatinase-associated lipocalin
• UniProt Gene Name: LCN2
• UniProt Synonym Gene Names: HNL; NGAL; NGAL
• UniProt Entry Name: NGAL_HUMAN