Quality Control Procedure
Mouse anti-Human OX-40/CD134 Monoclonal Antibody | anti-OX-40/CD134 antibody
OX-40/CD134
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
OX-40/CD134, Antibody; OX-40/CD134; anti-OX-40/CD134 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1
Clone Number
BSB-90
Form/Format
OX-40 / CD134 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Applicable Applications for anti-OX-40/CD134 antibody
IHC (Immunohistochemistry)
Localization
Cytoplasmic, Membranous
Control
Tonsil, Lymph Node, Thymus
Intended Use
For Analyte Specific Regent.
Analytical and performance characteristics for OX-40 antibody, BSB-90 are not established.
Analytical and performance characteristics for OX-40 antibody, BSB-90 are not established.
Immunogen
Synthetic peptide corresponding to the N-terminus of the human OX40 protein.
Precautions
1. This product contains <0.1% sodium azide (NaN3) as a preservative. Ensure proper handling procedures are used with this reagent.
2. Always wear personal protective equipment such as laboratory coat, goggles and gloves when handling reagents.
3. Dispose of unused solution with copious amount of water.
4. Do not ingest reagent. If reagent is ingested, seek medical advice immediately.
5. Avoid contact with eyes. If contact occurs, flush with large quantities of water.
6. Follow safety precautions 0fthe heating device used for epitope retrieval (Tinto Retriever Pressure Cooker or similar).
7. For additional safety information refer to Safety Data Sheet for this product.
8. For complete recommendations for handling biological specimens, please refer to the CDC document, Guidelines for Safe Work Practices in Human and Animal Laboratories” (see References in this document).
2. Always wear personal protective equipment such as laboratory coat, goggles and gloves when handling reagents.
3. Dispose of unused solution with copious amount of water.
4. Do not ingest reagent. If reagent is ingested, seek medical advice immediately.
5. Avoid contact with eyes. If contact occurs, flush with large quantities of water.
6. Follow safety precautions 0fthe heating device used for epitope retrieval (Tinto Retriever Pressure Cooker or similar).
7. For additional safety information refer to Safety Data Sheet for this product.
8. For complete recommendations for handling biological specimens, please refer to the CDC document, Guidelines for Safe Work Practices in Human and Animal Laboratories” (see References in this document).
Preparation and Storage
Store at 2 to 8 degree C.
Quality Control Procedure
Quality Control Procedure
IHC (Immunohiostchemistry)
(IHC of OX-40 on an FFPE Tissue)
IHC (Immunohiostchemistry)
(IHC of OX-40 on an FFPE Tissue)
Dilution Info
Dilution Info
Related Product Information for anti-OX-40/CD134 antibody
OX-40 also known as CD134 and Tumor Necrosis Factor Receptor Superfamily Member 4 (TNFRSF4), is a member of the TNFR-superfamily of receptors which is not constitutively expressed on activated CD4 and CD8 T cells as well as a number of other lymphoid and non-lymphoid cells, unlike CD28. OX40 and its binding partner, OX40L (CD252), are costimulatory signals from OX40 to a conventional T cell to promote division and survival, augmenting the clonal expansion of effector and memory populations as they are being generated to antigen. OX40 and OX40L also regulate cytokine production from T cells, antigen-presenting cells, NK cells, and NKT cells, and modulate cytokine receptor signaling. In line with these important modulatory functions, OX40/OX40L interactions have been found to play a central role in the development of multiple inflammatory and autoimmune diseases. Besides the essential role played by OX40 signaling in generating memory CD4 T cells, recent reports show that it also has a unique role in generating memory CD8 T cells. In addition, recent genome-wide association studies have identified single-nucleotide polymorphisms of the OX40L and OX40 genes that are related to cardiovascular diseases and SLE, providing direct evidence for the involvement of the OX40-OX40L interaction in human diseases.
OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and survival of T cells. Preclinical studies have shown that OX40 agonists increase antitumor immunity and improve tumor-free survival by increasing T and B cell responses to reporter antigen immunizations, led to preferential upregulation of OX40 on CD4(+) FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, and increased the antitumor reactivity of T and B cells in patients with melanoma.
OX40 is a potent costimulatory receptor that can potentiate T-cell receptor signaling on the surface of T lymphocytes, leading to their activation by a specifically recognized antigen. In particular, OX40 engagement by ligands present on dendritic cells dramatically increases the proliferation, effector function, and survival of T cells. Preclinical studies have shown that OX40 agonists increase antitumor immunity and improve tumor-free survival by increasing T and B cell responses to reporter antigen immunizations, led to preferential upregulation of OX40 on CD4(+) FoxP3(+) regulatory T cells in tumor-infiltrating lymphocytes, and increased the antitumor reactivity of T and B cells in patients with melanoma.
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Product Notes
The OX-40/CD134 (Catalog #AAA59298) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The OX-40/CD134 reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's OX-40/CD134 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the OX-40/CD134 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "OX-40/CD134, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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