Mouse anti-Human PP1C Monoclonal Antibody | anti-PPP1CC antibody

PP1C Antibody

Cat. Num. AAA290434

• Reactivity: Human
• Applications: Western Blot
• Synonyms: PP1C, Antibody; PP1C Antibody; Purified Mouse Monoclonal Antibody (Mab); EC 3.1.3.16; PP 1G; PP-1G; PP1G; PP1G_HUMAN; PP1gamma; PPP 1G; PPP1CC; PPP1CC protein; PPP1G; Protein phosphatase 1 catalytic subunit gamma isoform; Protein phosphatase 1C catalytic subunit; Protein phosphatase 1C subunit; Protein phosphatase 2C gamma isoform; Serine/threonine phosphatase 1 gamma; Serine/threonine protein phosphatase PP1 gamma catalytic subunit; Serine/threonine-protein phosphatase PP1-gamma catalytic subunit.; anti-PPP1CC antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG2b
• Form/Format: Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
• Sequence Length: 337

• Applicable Applications for anti-PPP1CC antibody: WB (Western Blot)
• Function: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.
• Cellular Location: Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle. Chromosome, centromere, kinetochore. Cleavage furrow. Midbody Mitochondrion. Cytoplasm, cytoskeleton, microtubule organizing center Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093) {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:12529430, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:17965019, ECO:0000269|PubMed:23789093}
• Preparation and Storage: Store at -20 °C. Stable for 12 months from date of receipt

WB (Western Blot)

(Western blot detection of PP1C in Hela,293T and Jurkat cell lysates using PP1C mouse mAb (1:500 diluted).Predicted band size:38KDa.Observed band size:38KDa.)

Related Product Information for anti-PPP1CC antibody

Background: Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density- associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E.

Product Categories/Family for anti-PPP1CC antibody

Cancer; Cell Biology; Metabolism; Neuroscience; Signal Transduction

References

Barker H.M.,et al.Biochim. Biophys. Acta 1178:228-233(1993). Bienvenut W.V.,et al.Submitted (MAR-2009) to UniProtKB. Bienvenut W.V.,et al.Submitted (JAN-2010) to UniProtKB. Norman S.A.,et al.Mamm. Genome 5:41-45(1994). MacKintosh R.W.,et al.FEBS Lett. 371:236-240(1995).

NCBI and Uniprot Product Information

• NCBI GI #: 350276247
• NCBI GeneID: 5501
• NCBI Accession #: NP_001231903.1
• NCBI GenBank Nucleotide #: NM_001244974.1
• UniProt Accession #: P36873
• Molecular Weight: 38kDa
• NCBI Official Full Name: serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2
• UniProt Protein Name: Serine/threonine-protein phosphatase PP1-gamma catalytic subunit
• UniProt Gene Name: PPP1CC
• UniProt Synonym Gene Names: PP-1G
• UniProt Entry Name: PP1G_HUMAN