Application Data
(Western blot analysis of K562 cell lysate using 0.5mg/mL mouse anti-PML mAb clone B3E9. The band shows on the blot is the 106KDa chimeric PML/RARa protein.)
Mouse promyelocytic leukemia protein Monoclonal Antibody | anti-PML antibody
mAb anti-human promyelocytic leukemia protein (PML)
Reactivity
Human. Others not tested
Applications
Western Blot
Purity
Protein G affinity purified
Synonyms
promyelocytic leukemia protein, Antibody; mAb anti-human promyelocytic leukemia protein (PML); Promyeloctic Leukemia (PML) [Ring Finger Domain]; Mouse monoclonal antibody to human promyelocytic leukemia protein (PML) ring finger domain; anti-PML antibody
Host
Mouse
Reactivity
Human. Others not tested
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
B3E9
Specificity
This antibody recognizes normal PML proteins of lower molecular weight, and also recognizes the high molecular weight PML/RARalpha chimeric protein in promyelocytic leukemia patients.
Promyeloctic Leukemia (PML) [Ring Finger Domain]
Promyeloctic Leukemia (PML) [Ring Finger Domain]
Purity/Purification
Protein G affinity purified
Form/Format
Lyophilized in pH 7.4, 0.01M PBS.
Applicable Applications for anti-PML antibody
WB (Western Blot)
Target Protein
Human PML and PML/RARalpha chimera
Immunogen
Recombinant partial human PML containing the ring finger domain
Myeloma
Sp2/0-Ag14
Reconstitution
Double distilled water is recommended to adjust the final concentration to 1.00mg/mL.
Research Area
Life science research, Oncology
Preparation and Storage
Store at -20 degree C
Application Data
(Western blot analysis of K562 cell lysate using 0.5mg/mL mouse anti-PML mAb clone B3E9. The band shows on the blot is the 106KDa chimeric PML/RARa protein.)
Application Data
(Western blot analysis of K562 cell lysate using 0.5mg/mL mouse anti-PML mAb clone B3E9. The band shows on the blot is the 106KDa chimeric PML/RARa protein.)
Related Product Information for anti-PML antibody
Acute promyelocytic leukemia (PML) is a type of acute myelogenous leukemia that is caused by the translocation of the retinoic acid receptor alpha (RAR?) gene at chromosome 17 to the promyelocytic leukemia (PML) gene at chromosome 15. The chimeric protein (PML/RAR?) has a higher molecular weight than normal PML protein. The altered proteins block DNA transcription and differentiation of granulocytes, reduce the production of red cells and platelets, consequently, resulting in anemia and thrombocytopenia.
Product Categories/Family for anti-PML antibody
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Product Notes
The PML (Catalog #AAA77899) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The mAb anti-human promyelocytic leukemia protein (PML) reacts with Human. Others not tested and may cross-react with other species as described in the data sheet. AAA Biotech's promyelocytic leukemia protein can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot). Researchers should empirically determine the suitability of the PML for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "promyelocytic leukemia protein, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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