WB (Western Blot)
(Western Blot analysis using R spondin1 antibodyWestern Blot showing R-spondin1 antibody used against recombinant R-spondin1 protein (1) and R-spondin1 (aa21-263)-hIgGFc transfected HEK293 cell lysate (2).)
Mouse R spondin1 Monoclonal Antibody | anti-RSPO1 antibody
R spondin1 antibody
Gene Names
RSPO1; RSPO; CRISTIN3
Applications
Western Blot, ELISA
Synonyms
R spondin1, Antibody; R spondin1 antibody; Monoclonal R spondin1 antibody, Anti-R spondin1 antibody, R spondin-1, R spondin 1 antibody, Rspondin1 antibody, RSPO1 antibody, CRISTIN3 antibody, R spondin1, R spondin 1, R-spondin1 antibody, FLJ40906 antibody, R spondin-1 antibody; anti-RSPO1 antibody
Host
Mouse
Clonality
Monoclonal
Isotype
IgG1
Clone Number
7A6
Form/Format
Supplied as a liquid in ascitic fluid containing 0.03% sodium azide.
Concentration
1.0 mg/ml (varies by lot)
Sequence Length
200
Applicable Applications for anti-RSPO1 antibody
WB (Western Blot), ELISA
Biological Significance
R spondin1 is a member of the R-spondin family and a secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects. It is an activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Cross-Reactivity
Human
Immunogen
R spondin1 antibody was raised in Mouse using a purified recombinant fragment of RSPO1 expressed in E Coli as the immunogen.
Preparation and Storage
Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.
WB (Western Blot)
(Western Blot analysis using R spondin1 antibodyWestern Blot showing R-spondin1 antibody used against recombinant R-spondin1 protein (1) and R-spondin1 (aa21-263)-hIgGFc transfected HEK293 cell lysate (2).)
WB (Western Blot)
(Western Blot analysis using R spondin1 antibodyWestern Blot showing R-spondin1 antibody used against recombinant R-spondin1 protein (1) and R-spondin1 (aa21-263)-hIgGFc transfected HEK293 cell lysate (2).)
Related Product Information for anti-RSPO1 antibody
Mouse monoclonal R spondin1 antibody
Product Categories/Family for anti-RSPO1 antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
21,775 Da
NCBI Official Full Name
R-spondin-1 isoform 3
NCBI Official Synonym Full Names
R-spondin 1
NCBI Official Symbol
RSPO1
NCBI Official Synonym Symbols
RSPO; CRISTIN3
NCBI Protein Information
R-spondin-1
UniProt Protein Name
R-spondin-1
UniProt Gene Name
RSPO1
UniProt Synonym Gene Names
hRspo1
UniProt Entry Name
RSPO1_HUMAN
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Product Notes
The RSPO1 rspo1 (Catalog #AAA106260) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's R spondin1 can be used in a range of immunoassay formats including, but not limited to, WB (Western Blot), ELISA. Researchers should empirically determine the suitability of the RSPO1 rspo1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "R spondin1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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