IHC (Immunohiostchemistry)
Mouse anti-Human Retinoblastoma (Rb) Monoclonal Antibody | anti-RB1 antibody
Retinoblastoma (Rb)
Gene Names
RB1; RB; pRb; OSRC; pp110; p105-Rb
Reactivity
Human
Synonyms
Retinoblastoma (Rb), Antibody; Retinoblastoma (Rb); anti-RB1 antibody
Host
Mouse
Reactivity
Human
Clonality
Monoclonal
Isotype
IgG1/K
Clone Number
SPM353
Form/Format
Anti-Retinoblastoma is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Control
Colon, Breast Cacinoma
Localization
Nuclear
Reactivity Note
Paraffin, Frozen
Preparation and Storage
Store at 2 to 8 degree C in the dark.
IHC (Immunohiostchemistry)
IHC (Immunohiostchemistry)
Dilution Info
Dilution Info
Related Product Information for anti-RB1 antibody
The retinoblastoma protein (Rb) is a tumor-suppressor protein that is dysfunctional in many types of cancer. One highly studied function of Rb is to prevent excessive cell growth by inhibiting cell-cycle progression until a cell is ready to divide. Rb prevents the cell from replicating damaged DNA by preventing its progression along the cell cycle through G1 into S. Should an oncogenic protein (such as that produced by cells infected with high-risk types of human papillomaviruses, SV40 or Adenoviruses) bind and inactivate Rb, this can lead to cancer. Rb protein may act by regulating transcription; loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and Leukemia.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
106,159 Da
NCBI Official Full Name
retinoblastoma
NCBI Official Synonym Full Names
retinoblastoma 1
NCBI Official Symbol
RB1
NCBI Official Synonym Symbols
RB; pRb; OSRC; pp110; p105-Rb
NCBI Protein Information
retinoblastoma-associated protein; OTTHUMP00000018397; retinoblastoma suspectibility protein
UniProt Protein Name
Retinoblastoma-associated protein
UniProt Gene Name
RB1
UniProt Entry Name
RB_HUMAN
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Product Notes
The RB1 rb1 (Catalog #AAA59260) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The Retinoblastoma (Rb) reacts with Human and may cross-react with other species as described in the data sheet. It is sometimes possible for the material contained within the vial of "Retinoblastoma (Rb), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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