Mouse anti-Human ROR2 Monoclonal Antibody | anti-ROR2 antibody

ROR2

Cat. Num. AAA215116

• Gene Names: ROR2; BDB; BDB1; NTRKR2
• Reactivity: Human
• Applications: Immunohistochemistry
• Purity: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Synonyms: ROR2, Antibody; ROR2; BR; CD49 antigen-like family member B; Collagen receptor; DX5; Glycoprotein Ia deficiency included (GPIa); Human platelet alloantigen system 5 (HPA5 included); Integrin alpha II (ITGA2); Platelet alloantigen Br(a); included; Platelet glycoprotein Ia/IIa; Platelet membrane glycoprotein Ia; VLA2;; anti-ROR2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: IgG
• Clone Number: ROR2/1911
• Specificity: ROR2 (receptor tyrosine kinase-like orphan receptor 2), also known as neurotrophic tyrosine kinase receptor-related 2 (NTRKR2), is a single pass transmembrane tyrosine-protein kinase receptor. It contains a cytoplasmic tyrosine kinase domain, distally located serine-threonine-rich domains, an extracellular immunoglobulin-like domain, a cysteine-rich domain and a kringle domain. ROR2 is important for skeletal and endocrine development and is required for cartilage and growth plate development. It promotes the differentiation of osteoblasts and plays an important role in the early formation of chondrocytes. ROR2 sequesters and associates with Dlxin-1 affecting the transcriptional function of Msx-2. ROR2 also interacts with canoncial Wnt-1 and Wnt-3, regulating their signaling pathways. Defects in ROR2 can result in the autosomal dominant skeletal disorder, brachydactyly type B1, or the autosomal recessive skeletal disorder, Robinow syndrome.
• Purity/Purification: Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
• Form/Format: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Sequence Length: 943

• Applicable Applications for anti-ROR2 antibody: IHC (Immunohistochemistry)
• Positive Control: Human breast, pancreas, kidney or GIST.
• Immunogen: Human cultured keratinocytes
• Cellular Localization: Cell Membrane.
• Hu-chromosome Location: 9q22.31
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C.; Antibody without azide: store at -20 to -80 degree C.; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

SDS-PAGE

(SDS-PAGE Analysis Purified ROR2 Mouse Monoclonal Antibody (ROR2/1911). Confirmation of Purity and Integrity of Antibody.)

IHC (Immunohistochemistry)

(Formalin-fixed, paraffin-embedded human Kidney stained with ROR2 Mouse Monoclonal Antibody (ROR2/1911).)

References

Yu, J., et al. 2016. J. Clin. Invest. 126: 585-598.

NCBI and Uniprot Product Information

• NCBI GI #: 90110767
• NCBI GeneID: 4920
• UniProt Accession #: Q01974
• Molecular Weight: 120kDa
• NCBI Official Full Name: Tyrosine-protein kinase transmembrane receptor ROR2
• NCBI Official Synonym Full Names: receptor tyrosine kinase like orphan receptor 2
• NCBI Official Symbol: ROR2
• NCBI Official Synonym Symbols: BDB; BDB1; NTRKR2
• NCBI Protein Information: tyrosine-protein kinase transmembrane receptor ROR2
• UniProt Protein Name: Tyrosine-protein kinase transmembrane receptor ROR2
• UniProt Gene Name: ROR2
• UniProt Synonym Gene Names: NTRKR2
• UniProt Entry Name: ROR2_HUMAN