Mouse RPS6KA5/MSK1 Monoclonal Antibody | anti-RPS6KA5 antibody

RPS6KA5/MSK1 Mouse Monoclonal Antibody [Clone PCRP-RPS6KA5-1A8]

Cat. Num. AAA216043

• Gene Names: RPS6KA5; MSK1; RLPK; MSPK1
• Reactivity: Human; Predicted to react with Mouse and Rat.
• Applications: Western Blot, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: RPS6KA5/MSK1, Antibody; RPS6KA5/MSK1 Mouse Monoclonal Antibody [Clone PCRP-RPS6KA5-1A8]; 90kDa ribosomal protein S6 kinase 5; EC 2. 7. 11. 1; Mitogen and stress activated protein kinase 1; MSPK1; Nuclear Mitogen And Stress Activated Protein Kinase 1; Ribosomal protein S6 kinase 90kD polypeptide 5; Ribosomal Protein S6 Kinase Alpha 5; RLPK; RPS6KA5; RSK Like Protein Kinase; RSKL; S6K alpha 5; anti-RPS6KA5 antibody

• Host: Mouse
• Reactivity: Human; Predicted to react with Mouse and Rat.
• Clonality: Monoclonal
• Isotype: Mouse/IgG2b
• Clone Number: PCRP-RPS6KA5-1A8
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Concentration: Purified Ab with BSA and Azide at 200ug/ml; OR; Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)

• Applicable Applications for anti-RPS6KA5 antibody: WB (Western Blot), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
• Immunogen: Recombinant full-length human RPS6KA5 protein
• Cellular Localization: Nucleus, Cytoplasm, Predominantly nuclear, Partially cytoplasmic
• Positive Control: HeLa or JAR cells. Ubiquitous nuclear expression. Human prostate, tonsil or brain.
• Hu-chromosome Location: 14q32.11
• Unigene: 510225
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

FCM/FACS (Flow Cytometry)

(Flow Cytometric Analysis of PFA-fixed HeLa cells. RPS6KA5/MSK1 Mouse Monoclonal Antibody (PCRP-RPS6KA5-1A8) followed by goat anti-mouse IgG-CF488 (blue); isotype control (red).)

Related Product Information for anti-RPS6KA5 antibody

The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.

NCBI and Uniprot Product Information

• NCBI GI #: 32528295
• NCBI GeneID: 9252
• NCBI Accession #: NP_004746.2
• NCBI GenBank Nucleotide #: NM_004755.2
• UniProt Accession #: O75582; O95316; Q96AF7
• Molecular Weight: 89,865 Da
• NCBI Official Full Name: ribosomal protein S6 kinase alpha-5 isoform a
• NCBI Official Synonym Full Names: ribosomal protein S6 kinase, 90kDa, polypeptide 5
• NCBI Official Symbol: RPS6KA5
• NCBI Official Synonym Symbols: MSK1; RLPK; MSPK1
• NCBI Protein Information: ribosomal protein S6 kinase alpha-5; RSKL; S6K-alpha-5; RSK-like protein kinase; 90 kDa ribosomal protein S6 kinase 5; nuclear mitogen- and stress-activated protein kinase 1
• UniProt Protein Name: Ribosomal protein S6 kinase alpha-5
• UniProt Gene Name: RPS6KA5
• UniProt Synonym Gene Names: MSK1; S6K-alpha-5; RSKL
• UniProt Entry Name: KS6A5_HUMAN