ICC (Immunocytochemistry)
(Immunocytochemistry of Survivin (green) in MCF-7 using Survivin antibody at dilution 1/20, and DAPI(blue))
anti-Human Survivin Monoclonal Antibody | anti-Survivin antibody
Survivin Rabbit mAb
Gene Names
BIRC5; API4; EPR-1
Reactivity
Human
Applications
Immunofluorescence, Western Blot
Purity
Affinity Purified
Synonyms
Survivin, Antibody; Survivin Rabbit mAb; API4; EPR-1; anti-Survivin antibody
Host
Recombinant Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit IgG
Clone Number
S04-1B1
Purity/Purification
Affinity Purified
Form/Format
50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Concentration
0.3mg/ml (varies by lot)
Applicable Applications for anti-Survivin antibody
IF (Immunofluorescence), WB (Western Blot)
Immunogen
Recombinant protein of human Survivin
Conjugation
Unconjugated
Modification
Unmodification
Preparation and Storage
Store at 4 degree C short term. Aliquot and store at -20 degree C long term. Avoid freeze/thaw cycles.
ICC (Immunocytochemistry)
(Immunocytochemistry of Survivin (green) in MCF-7 using Survivin antibody at dilution 1/20, and DAPI(blue))
ICC (Immunocytochemistry)
(Immunocytochemistry of Survivin (green) in MCF-7 using Survivin antibody at dilution 1/20, and DAPI(blue))
WB (Western Blot)
(Western blot detection of Survivin in Jurkat cell lysates using Survivin Rabbit mAb(1:500 diluted).Predicted band size:16kDa.Observed band size:16kDa.)
WB (Western Blot)
(Western blot detection of Survivin in Jurkat cell lysates using Survivin Rabbit mAb(1:500 diluted).Predicted band size:16kDa.Observed band size:16kDa.)
Related Product Information for anti-Survivin antibody
Multitasking protein that has dual roles in promoting cell proliferation and preventing apoptosis (PubMed:9859993, PubMed:21364656, PubMed:20627126). Component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis (PubMed:16322459). Acts as an important regulator of the localization of this complex; directs CPC movement to different locations from the inner centromere during prometaphase to midbody during cytokinesis and participates in the organization of the center spindle by associating with polymerized microtubules (PubMed:20826784). Involved in the recruitment of CPC to centromeres during early mitosis via association with histone H3 phosphorylated at 'Thr-3' (H3pT3) during mitosis (PubMed:20929775). The complex with RAN plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules (PubMed:18591255). May counteract a default induction of apoptosis in G2/M phase (PubMed:9859993). The acetylated form represses STAT3 transactivation of target gene promoters (PubMed:20826784). May play a role in neoplasia (PubMed:10626797). Inhibitor of CASP3 and CASP7 (PubMed:21536684). Isoform 2 and isoform 3 do not appear to play vital roles in mitosis (PubMed:12773388, PubMed:16291752). Isoform 3 shows a marked reduction in its anti-apoptotic effects when compared with the displayed wild-type isoform (PubMed:10626797).
Product Categories/Family for anti-Survivin antibody
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
16,389 Da
NCBI Official Full Name
baculoviral IAP repeat-containing protein 5 isoform 2
NCBI Official Synonym Full Names
baculoviral IAP repeat containing 5
NCBI Official Symbol
BIRC5
NCBI Official Synonym Symbols
API4; EPR-1
NCBI Protein Information
baculoviral IAP repeat-containing protein 5; apoptosis inhibitor 4; survivin variant 3 alpha; apoptosis inhibitor survivin
UniProt Protein Name
Baculoviral IAP repeat-containing protein 5
UniProt Gene Name
BIRC5
UniProt Synonym Gene Names
API4; IAP4
UniProt Entry Name
BIRC5_HUMAN
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Product Notes
The Survivin birc5 (Catalog #AAA314471) is an Antibody produced from Recombinant Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Survivin Rabbit mAb reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's Survivin can be used in a range of immunoassay formats including, but not limited to, IF (Immunofluorescence), WB (Western Blot). Researchers should empirically determine the suitability of the Survivin birc5 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Survivin, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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