IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human spleen stained with TIA-1 Recombinant Rabbit Monoclonal Antibody (TIA/1352R).)
Rabbit anti-Human TIA1 (T-Cell-Restricted Intracellular Antigen-1) Monoclonal Antibody | anti-TIA1 antibody
TIA1 (T-Cell-Restricted Intracellular Antigen-1) Recombinant Rabbit Monoclonal Antibody [Clone TIA1/1352R]
Gene Names
TIA1; WDM; TIA-1
Reactivity
Human
Applications
Immunohistochemistry
Synonyms
TIA1 (T-Cell-Restricted Intracellular Antigen-1), Antibody; TIA1 (T-Cell-Restricted Intracellular Antigen-1) Recombinant Rabbit Monoclonal Antibody [Clone TIA1/1352R]; Cytotoxic granule associated RNA binding protein 1; mTIA-1; Nucleolysin TIA1 isoform p40; p40-TIA-1; RNA binding protein TIA1; TIAL1; TIAR; WDM; anti-TIA1 antibody
Host
Rabbit
Reactivity
Human
Clonality
Monoclonal
Isotype
Rabbit/IgG
Clone Number
TIA1/1352R
Form/Format
200ug/ml of Ab purified from rabbit anti-serum by Protein A. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA at 1.0mg/ml.
Concentration
Purified Ab with BSA and Azide at 200ug/ml
OR
Purified Ab WITHOUT BSA at 1.0mg/ml (varies by lot)
OR
Purified Ab WITHOUT BSA at 1.0mg/ml (varies by lot)
Applicable Applications for anti-TIA1 antibody
IHC (Immunohistochemistry)
Antibody Type
Recombinant Antibody
Immunogen
Human bone marrow malignant cells from a non B, non T acute leukemia
Cellular Localization
Cytoplasmic granule, Nucleus, Accumulates in cytoplasmic stress granules (SG) following cellular damage
Positive Control
Human tonsil, spleen and lymph node.
Hu-chromosome Location
2p13
Unigene
413123
Preparation and Storage
Antibody with azide: store at 2 to 8 degree C
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide: store at -20 to -80 degree C
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human spleen stained with TIA-1 Recombinant Rabbit Monoclonal Antibody (TIA/1352R).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human spleen stained with TIA-1 Recombinant Rabbit Monoclonal Antibody (TIA/1352R).)
Related Product Information for anti-TIA1 antibody
The T cell intracellular antigen 1 (TIA 1) is a 17 kDa cytoplasmic granule associated protein also designated as GMP 17, for granule membrane protein of 17 kDa. The GMP 17/TIA 1 molecule is expressed in cells possessing cytolytic potential and could be involved in the signaling cascade of Fas (CD95) mediated apoptosis. Within hematopoietic cell lines, the TIA1/1352R monoclonal antibody reacts with about 90% of CD16+, 50 60% of CD8+, and less than 10% of CD4+ normal peripheral blood lymphocytes. It reacts with almost all monocytes and granulocytes. This antibody also reacts with CD4+ activated T cell clones, activated NK cell clones, and Con activated thymocytes, but not with B lymphocytes or B cell lines. TIA1 antibody labels cytotoxic T cells and natural killer cells (NK cells). It is also expressed in T-cell lymphoma, large granular lymphocyte (LGL) leukemia and hairy cell leukemia. TIA1 expression in T-cell malignancies may help in differentiating LGL leukemia (high expression) from T-cell lymphocytosis and other T-cell diseases (low expression). TIA1 may also be used to label tumor-infiltrating lymphocytes in the study of immune response to malignancies.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
41,801 Da
NCBI Official Full Name
Nucleolysin TIA-1 isoform p40
NCBI Official Synonym Full Names
TIA1 cytotoxic granule-associated RNA binding protein
NCBI Official Symbol
TIA1
NCBI Official Synonym Symbols
WDM; TIA-1
NCBI Protein Information
nucleolysin TIA-1 isoform p40; p40-TIA-1 (containing p15-TIA-1); T-cell-restricted intracellular antigen-1
UniProt Protein Name
Nucleolysin TIA-1 isoform p40
UniProt Gene Name
TIA1
UniProt Synonym Gene Names
TIA-1
UniProt Entry Name
TIA1_HUMAN
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Product Notes
The TIA1 tia1 (Catalog #AAA215956) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TIA1 (T-Cell-Restricted Intracellular Antigen-1) Recombinant Rabbit Monoclonal Antibody [Clone TIA1/1352R] reacts with Human and may cross-react with other species as described in the data sheet. AAA Biotech's TIA1 (T-Cell-Restricted Intracellular Antigen-1) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the TIA1 tia1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TIA1 (T-Cell-Restricted Intracellular Antigen-1), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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