Application Data
(Immunoperoxidase staining of formalin fixed, paraffin embedded human small intestine tissue showing cytoplasmic staining of glandular cells.)
Mouse TNFR1 Monoclonal Antibody | anti-TNFR1 antibody
TNFR1
Gene Names
TNFRSF1A; FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55
Reactivity
Human, Mouse, Rat
Applications
Immunohistochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Purity
Immunogen affinity purified
Synonyms
TNFR1, Antibody; TNFR1; Tumor necrosis factor receptor 1; anti-TNFR1 antibody
Host
Mouse
Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Isotype
IgG
Clone Number
2G2
Purity/Purification
Immunogen affinity purified
Form/Format
1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin.
Sequence Length
455
Applicable Applications for anti-TNFR1 antibody
IHC (Immunohistochemistry), IF (Immunofluorescence), IP (Immunoprecipitation), WB (Western Blot)
Immunogen
Amino acids 30-301 mapping within the extracellular domain of TNF-R1 of human origin.
Positive Control
Hela, MCF7, U-937, human small intestine tissue
Subcellular Location
Secreted, Golgi apparatus membrane Cell membrane
Preparation and Storage
Store at 4 degrees C for short term, store at -20 degrees C for long term. Avoid multiple thaw/freeze
Application Data
(Immunoperoxidase staining of formalin fixed, paraffin embedded human small intestine tissue showing cytoplasmic staining of glandular cells.)
Application Data
(Immunoperoxidase staining of formalin fixed, paraffin embedded human small intestine tissue showing cytoplasmic staining of glandular cells.)
WB (Western Blot)
(Western blot analysis of TNF-R1 expression in MCF7 (A), HeLa (B) and U-937 (C) whole cell lysates.)
WB (Western Blot)
(Western blot analysis of TNF-R1 expression in MCF7 (A), HeLa (B) and U-937 (C) whole cell lysates.)
Related Product Information for anti-TNFR1 antibody
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors. These receptors, designated TNF-R1 and TNF-R2 are expressed on most cell types. The majority of TNF functions are primarily mediated through TNF-R1, while signaling through TNF-R2 occurs less extensively and is confined to cells of the immune system. Both of these proteins belong to the growing TNF and nerve growth factor (NGF) receptor superfamily, which includes FAS, CD30, CD27 and CD40. The members of this superfamily are type I membrane proteins that share sequence homology confined to the extracellular region. TNF-R1 shares a motif coined the “death domain” with FAS and three structurally unrelated signaling proteins, TRADD, FADD and RIP. This “death domain” is required for transduction of the apoptotic signal.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55 kDa
NCBI Official Full Name
tumor necrosis factor receptor superfamily member 1A isoform 1
NCBI Official Synonym Full Names
TNF receptor superfamily member 1A
NCBI Official Symbol
TNFRSF1A
NCBI Official Synonym Symbols
FPF; p55; p60; TBP1; TNF-R; TNFAR; TNFR1; p55-R; CD120a; TNFR55; TNFR60; TNF-R-I; TNF-R55
NCBI Protein Information
tumor necrosis factor receptor superfamily member 1A
UniProt Protein Name
Tumor necrosis factor receptor superfamily member 1A
UniProt Gene Name
TNFRSF1A
UniProt Synonym Gene Names
TNFAR; TNFR1; TNF-R1; TNF-RI; TNFR-I; TBPI
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Product Notes
The TNFR1 tnfrsf1a (Catalog #AAA268461) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TNFR1 reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TNFR1 can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry), IF (Immunofluorescence), IP (Immunoprecipitation), WB (Western Blot). Researchers should empirically determine the suitability of the TNFR1 tnfrsf1a for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TNFR1, Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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