Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using TRAF1 Mouse Monoclonal Antibody (TRAF1/2770). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Mouse TRAF1 (TNFR-Associated Factor 1) Monoclonal Antibody | anti-TRAF1 antibody
TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker)
Gene Names
TRAF1; EBI6; MGC:10353
Reactivity
Human. Others not known
Applications
Immunohistochemistry
Purity
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Synonyms
TRAF1 (TNFR-Associated Factor 1), Antibody; TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker); EBI6; EBV induced protein 6; Epstein-Barr virus-induced protein 6; TNF receptor-associated factor 1; TRAF1; anti-TRAF1 antibody
Host
Mouse
Reactivity
Human. Others not known
Clonality
Monoclonal
Isotype
IgG1, kappa
Clone Number
TRAF1/2770
Specificity
This MAb recognizes a protein of 52kDa, which is identified as TNFR1 (TNFR-associated factor 1). CD30-positive lymphoproliferations of the skin comprise 30% of all primary cutaneous T-cell lymphomas (CTCLs). Besides borderline cases this group includes lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large T-cell lymphoma (cALCL). Although the two entities overlap clinically, histopathologically, immunopathologically and genetically, they differ considerably in their prognosis. In particular, common feature of both cases is histologically the presence of atypical lymphoid CD30-positive T blasts and genetically a clonal T-cell-receptor rearrangement. However, both cases differ considerably in their clinical course: Lesions of LyP regress spontaneously, whereas those of cALCL persist and may progress and spread. Moreover, LyP patients do not benefit from an aggressive radio- and/or chemotherapeutic approach, in contrast to patients with cALCL. Besides, LyP and cALCL differ strongly in the expression of TRAF1 (tumor necrosis factor receptor (TNFR)-associated factor 1), a component of TNFR signaling: Whereas tumor cells of most LyP cases (ca. 84%) show a strong TRAF1 expression, tumor cells of cALCL reveal TRAF1 expression in only a few cases (ca. 7%). Antibody to TRAF1 is highly useful for the differentiation of LyP and cALCL in patients with cutaneous CD30-positive lymphoproliferations.
Purity/Purification
Purified Ab with BSA and Azide at 200ug/ml OR Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
Form/Format
200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Sequence Length
294
Applicable Applications for anti-TRAF1 antibody
IHC (Immunohistochemistry)
Immunogen
Recombinant fragment of human TRAF1 protein (around aa 73-219) (exact sequence is proprietary)
Positive Control
HeLa or 293T Cells. Hodgkins Lymphoma
Cellular Localization
Cytoplasmic
Chromosome Location
9q33.2
Preparation and Storage
Antibody with azide - store at 2 to 8 degree C.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Antibody without azide - store at -20 to -80 degree C.
Antibody is stable for 24 months. Non-hazardous. No MSDS required.
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using TRAF1 Mouse Monoclonal Antibody (TRAF1/2770). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
Application Data
(Analysis of Protein Array containing more than 19,000 full-length human proteins using TRAF1 Mouse Monoclonal Antibody (TRAF1/2770). Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (MAb) (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProtTM array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProtTM are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a MAb to its intended target. A MAb is considered to specific to its intended target, if the MAb has an S-score of at least 2.5. For example, if a MAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that MAb to protein X is equal to 29.)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Lymph Node stained with TRAF1 Mouse Monoclonal Antibody (TRAF1/2770).)
IHC (Immunohiostchemistry)
(Formalin-fixed, paraffin-embedded human Lymph Node stained with TRAF1 Mouse Monoclonal Antibody (TRAF1/2770).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Spleen stained with TRAF1 Mouse Monoclonal Antibody (TRAF1/2770).)
IHC (Immunohistochemistry)
(Formalin-fixed, paraffin-embedded human Spleen stained with TRAF1 Mouse Monoclonal Antibody (TRAF1/2770).)
References
Assaf C., et al. J Invest Dermatol 127(8):1898-1904, 2007
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
52kDa
NCBI Official Full Name
TNF receptor-associated factor 1 isoform a
NCBI Official Synonym Full Names
TNF receptor associated factor 1
NCBI Official Symbol
TRAF1
NCBI Official Synonym Symbols
EBI6; MGC:10353
NCBI Protein Information
TNF receptor-associated factor 1
UniProt Protein Name
TNF receptor-associated factor 1
UniProt Gene Name
TRAF1
UniProt Synonym Gene Names
EBI6
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Product Notes
The TRAF1 traf1 (Catalog #AAA214827) is an Antibody produced from Mouse and is intended for research purposes only. The product is available for immediate purchase. The TRAF1 (TNFR-Associated Factor 1) (Lymphomatoid Papulosis Marker) reacts with Human. Others not known and may cross-react with other species as described in the data sheet. AAA Biotech's TRAF1 (TNFR-Associated Factor 1) can be used in a range of immunoassay formats including, but not limited to, IHC (Immunohistochemistry). Researchers should empirically determine the suitability of the TRAF1 traf1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRAF1 (TNFR-Associated Factor 1), Monoclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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