Mouse anti-Human TRBP2/TARBP2 Monoclonal Antibody | anti-TARBP2 antibody

TRBP2/TARBP2 Mouse Monoclonal Antibody [Clone PCRP-TARBP2-1E5]

Cat. Num. AAA215952

• Gene Names: TARBP2; LOQS; TRBP; TRBP1; TRBP2
• Reactivity: Human
• Applications: Western Blot, Immunofluorescence, Flow Cytometry, Functional Assay
• Synonyms: TRBP2/TARBP2, Antibody; TRBP2/TARBP2 Mouse Monoclonal Antibody [Clone PCRP-TARBP2-1E5]; LOQS; Prbp; RISC loading complex subunit TARBP2; TAR (HIV 1) RNA binding protein 2; TAR RNA Binding Protein 2; TARBP2 RISC loading complex RNA binding subunit; Trans-activation-responsive RNA-binding protein; TRBP; TRBP1; anti-TARBP2 antibody

• Host: Mouse
• Reactivity: Human
• Clonality: Monoclonal
• Isotype: Mouse/IgG2a
• Clone Number: PCRP-TARBP2-1E5
• Form/Format: 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0. 05% BSA & 0. 05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
• Concentration: Purified Ab with BSA and Azide at 200ug/ml; OR; Purified Ab WITHOUT BSA and Azide at 1.0mg/ml (varies by lot)

• Applicable Applications for anti-TARBP2 antibody: WB (Western Blot), IF (Immunofluorescence), FCM/FACS (Flow Cytometry)
• Immunogen: Recombinant full-length human TARBP2 protein
• Cellular Localization: Cytoplasm, Cytoplasm > perinuclear region, Nucleus
• Positive Control: MCF-7 or HeLa cells.
• Hu-chromosome Location: 12q13.13
• Unigene: 326
• Preparation and Storage: Antibody with azide: store at 2 to 8 degree C; Antibody without azide: store at -20 to -80 degree C; Antibody is stable for 24 months. Non-hazardous. No MSDS required.

FCM/FACS (Flow Cytometry)

(Flow Cytometric Analysis of PFA-fixed HeLa cells. TRBP2/TARBP2 Mouse Monoclonal Antibody (PCRP-TARBP2-1E5) followed by goat anti-mouse IgG-CF488 (blue); unstained cells (red).)

Related Product Information for anti-TARBP2 antibody

TRBP2, also known as TARBP2 (trans-activation-responsive (HIV-1) RNA binding protein 2), TRBP1 or TRBP, is a nuclear protein that contains three DRBM (double-stranded RNA-binding) domains. TRBP binds between the bulge and the loop of the HIV-1 TAR RNA regulatory element and activates HIV-1 gene expression in synergy with the viral Tat protein. The third DRBM motif in the C-terminus of human TRBP2 can interact with and inhibit PKR activity, thereby increasing HIV-1 long terminal repeat (LTR) expression. In addition, TRBP2 functions as a component of a Dicer-containing complex and associates with the catalytic subunit of the RNA-induced silencing complex (RISC), namely eIF2C2. TRBP2 is essential for Dicer stability and the proper assembly of RISC. This suggests that TRBP2, in association with Dicer, plays an important role in the processing of miRNAs (microRNAs).

NCBI and Uniprot Product Information

• NCBI GI #: 209572714
• NCBI GeneID: 6895
• UniProt Accession #: Q15633; Q12878; Q8WY32; Q8WY33; Q9BRY2
• Molecular Weight: 366
• NCBI Official Full Name: RISC-loading complex subunit TARBP2
• NCBI Official Synonym Full Names: TAR (HIV-1) RNA binding protein 2
• NCBI Official Symbol: TARBP2
• NCBI Official Synonym Symbols: LOQS; TRBP; TRBP1; TRBP2
• NCBI Protein Information: RISC-loading complex subunit TARBP2; TAR RNA binding protein 2; TAR RNA-binding protein 2; TAR (HIV) RNA binding protein 2; TAR (HIV) RNA-binding protein 2; TAR (HIV) RNA-binding protein TRBP1; trans-activation responsive RNA-binding protein; trans-activa
• UniProt Protein Name: RISC-loading complex subunit TARBP2
• UniProt Gene Name: TARBP2
• UniProt Entry Name: TRBP2_HUMAN